Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1140161..1140675 Replicon chromosome
Accession NZ_CP077894
Organism Staphylococcus aureus strain 329

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag KU540_RS05530 Protein ID WP_000581795.1
Coordinates 1140466..1140675 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag KU540_RS05525 Protein ID WP_000138934.1
Coordinates 1140161..1140454 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU540_RS05505 (1135487) 1135487..1136128 + 642 WP_225805902.1 thiamine phosphate synthase -
KU540_RS05510 (1136214) 1136214..1137086 + 873 WP_000725802.1 membrane protein insertase YidC -
KU540_RS05515 (1137836) 1137836..1138483 - 648 WP_001187624.1 HD domain-containing protein -
KU540_RS05520 (1138511) 1138511..1139995 - 1485 WP_000571558.1 cardiolipin synthase -
KU540_RS05525 (1140161) 1140161..1140454 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU540_RS05530 (1140466) 1140466..1140675 + 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
KU540_RS05535 (1140803) 1140803..1140940 + 138 WP_000828354.1 Lmo0850 family protein -
KU540_RS05540 (1141204) 1141204..1142406 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU540_RS05545 (1142724) 1142724..1143794 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU540_RS05550 (1143809) 1143809..1145167 + 1359 WP_060649657.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T208446 WP_000581795.1 NZ_CP077894:1140466-1140675 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208446 NZ_CP103645:c2476142-2475966 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT208446 WP_000138934.1 NZ_CP077894:1140161-1140454 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208446 NZ_CP103645:c2475920-2475504 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References