Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1761113..1761590 | Replicon | chromosome |
| Accession | NZ_CP077893 | ||
| Organism | Staphylococcus aureus strain 332 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q2G005 |
| Locus tag | KU542_RS08920 | Protein ID | WP_000052078.1 |
| Coordinates | 1761402..1761590 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | KU542_RS08915 | Protein ID | WP_001059690.1 |
| Coordinates | 1761113..1761373 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU542_RS08880 (1756506) | 1756506..1757222 | - | 717 | WP_000150017.1 | type I 3-dehydroquinate dehydratase | - |
| KU542_RS08885 (1757370) | 1757370..1757792 | + | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| KU542_RS08890 (1758191) | 1758191..1758685 | + | 495 | WP_225806481.1 | GNAT family N-acetyltransferase | - |
| KU542_RS08895 (1758840) | 1758840..1759457 | + | 618 | WP_182055367.1 | LysE/ArgO family amino acid transporter | - |
| KU542_RS08900 (1759530) | 1759530..1760111 | - | 582 | WP_001140686.1 | histidine phosphatase family protein | - |
| KU542_RS08905 (1760336) | 1760336..1760572 | + | 237 | WP_000368687.1 | hypothetical protein | - |
| KU542_RS08910 (1760569) | 1760569..1760772 | - | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| KU542_RS08915 (1761113) | 1761113..1761373 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| KU542_RS08920 (1761402) | 1761402..1761590 | + | 189 | WP_000052078.1 | hypothetical protein | Toxin |
| KU542_RS08925 (1761778) | 1761778..1762347 | + | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
| KU542_RS08930 (1762435) | 1762435..1762719 | + | 285 | WP_001004395.1 | hypothetical protein | - |
| KU542_RS08935 (1762781) | 1762781..1762999 | + | 219 | WP_000005886.1 | hypothetical protein | - |
| KU542_RS08940 (1763495) | 1763495..1763695 | - | 201 | WP_001059082.1 | cold-shock protein | - |
| KU542_RS08945 (1764052) | 1764052..1764738 | - | 687 | WP_001548082.1 | thermonuclease family protein | - |
| KU542_RS08950 (1765079) | 1765079..1765549 | - | 471 | WP_000824472.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7172.84 Da Isoelectric Point: 9.9971
>T208443 WP_000052078.1 NZ_CP077893:1761402-1761590 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T208443 NZ_CP103645:c1860889-1860512 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACATACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACATACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT208443 WP_001059690.1 NZ_CP077893:1761113-1761373 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT208443 NZ_CP103645:c1861347-1860979 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D6HZ40 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |