Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 496240..496754 Replicon chromosome
Accession NZ_CP077893
Organism Staphylococcus aureus strain 332

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU542_RS02555 Protein ID WP_000581792.1
Coordinates 496545..496754 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU542_RS02550 Protein ID WP_000138932.1
Coordinates 496240..496533 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU542_RS02530 (491503) 491503..492144 + 642 WP_000483153.1 thiamine phosphate synthase -
KU542_RS02535 (492230) 492230..493102 + 873 WP_000725802.1 membrane protein insertase YidC -
KU542_RS02540 (493915) 493915..494562 - 648 WP_001187629.1 HD domain-containing protein -
KU542_RS02545 (494590) 494590..496074 - 1485 WP_000571549.1 cardiolipin synthase -
KU542_RS02550 (496240) 496240..496533 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU542_RS02555 (496545) 496545..496754 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU542_RS02560 (496882) 496882..497019 + 138 WP_000828354.1 Lmo0850 family protein -
KU542_RS02565 (497283) 497283..498485 - 1203 WP_001109935.1 FtsW/RodA/SpoVE family cell cycle protein -
KU542_RS02570 (498803) 498803..499873 + 1071 WP_000159633.1 D-alanine--D-alanine ligase -
KU542_RS02575 (499888) 499888..501246 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208435 WP_000581792.1 NZ_CP077893:496545-496754 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208435 NZ_CP103645:185543-185650 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208435 WP_000138932.1 NZ_CP077893:496240-496533 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208435 NZ_CP103645:c185495-185429 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References