Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2476929..2477458 Replicon chromosome
Accession NZ_CP077889
Organism Staphylococcus aureus strain 333

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KU539_RS12190 Protein ID WP_000621175.1
Coordinates 2476929..2477291 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag KU539_RS12195 Protein ID WP_000948331.1
Coordinates 2477288..2477458 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU539_RS12170 (2473907) 2473907..2474677 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
KU539_RS12175 (2474652) 2474652..2475131 - 480 WP_001190829.1 anti-sigma B factor RsbW -
KU539_RS12180 (2475133) 2475133..2475459 - 327 WP_001052491.1 anti-sigma factor antagonist -
KU539_RS12185 (2475578) 2475578..2476579 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
KU539_RS12190 (2476929) 2476929..2477291 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KU539_RS12195 (2477288) 2477288..2477458 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KU539_RS12200 (2477543) 2477543..2478691 - 1149 WP_001281145.1 alanine racemase -
KU539_RS12205 (2478757) 2478757..2479116 - 360 WP_000581200.1 holo-ACP synthase -
KU539_RS12210 (2479120) 2479120..2479611 - 492 WP_001205910.1 PH domain-containing protein -
KU539_RS12215 (2479598) 2479598..2481181 - 1584 WP_001294626.1 PH domain-containing protein -
KU539_RS12220 (2481174) 2481174..2481653 - 480 WP_001287088.1 hypothetical protein -
KU539_RS12225 (2481861) 2481861..2482421 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T208420 WP_000621175.1 NZ_CP077889:c2477291-2476929 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T208420 NZ_CP103639:1968421-1968524 [Klebsiella aerogenes]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT208420 WP_000948331.1 NZ_CP077889:c2477458-2477288 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT208420 NZ_CP103639:c1968532-1968386 [Klebsiella aerogenes]
TAATAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAA
GTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTGACTGTGACAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References