Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1231849..1232326 Replicon chromosome
Accession NZ_CP077889
Organism Staphylococcus aureus strain 333

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag KU539_RS05910 Protein ID WP_000052078.1
Coordinates 1231849..1232037 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU539_RS05915 Protein ID WP_001059690.1
Coordinates 1232066..1232326 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU539_RS05880 (1227890) 1227890..1228360 + 471 WP_000824472.1 hypothetical protein -
KU539_RS05885 (1228701) 1228701..1229387 + 687 WP_001548082.1 thermonuclease family protein -
KU539_RS05890 (1229744) 1229744..1229944 + 201 WP_001059082.1 cold-shock protein -
KU539_RS05895 (1230440) 1230440..1230658 - 219 WP_000005886.1 hypothetical protein -
KU539_RS05900 (1230720) 1230720..1231004 - 285 WP_001004395.1 hypothetical protein -
KU539_RS05905 (1231092) 1231092..1231661 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KU539_RS05910 (1231849) 1231849..1232037 - 189 WP_000052078.1 hypothetical protein Toxin
KU539_RS05915 (1232066) 1232066..1232326 - 261 WP_001059690.1 hypothetical protein Antitoxin
KU539_RS05920 (1232667) 1232667..1232870 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU539_RS05925 (1232867) 1232867..1233103 - 237 WP_000368687.1 hypothetical protein -
KU539_RS05930 (1233328) 1233328..1233909 + 582 WP_001140686.1 histidine phosphatase family protein -
KU539_RS05935 (1233982) 1233982..1234599 - 618 WP_182055367.1 LysE/ArgO family amino acid transporter -
KU539_RS05940 (1234754) 1234754..1235248 - 495 WP_225806481.1 GNAT family N-acetyltransferase -
KU539_RS05945 (1235647) 1235647..1236069 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
KU539_RS05950 (1236217) 1236217..1236933 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T208412 WP_000052078.1 NZ_CP077889:c1232037-1231849 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208412 NZ_CP103635:c4696912-4696379 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208412 WP_001059690.1 NZ_CP077889:c1232326-1232066 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208412 NZ_CP103635:c4697189-4696923 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References