208408

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1808937..1809414 Replicon chromosome
Accession NZ_CP077888
Organism Staphylococcus aureus strain 334

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag KU519_RS09165 Protein ID WP_000052078.1
Coordinates 1808937..1809125 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU519_RS09170 Protein ID WP_001059690.1
Coordinates 1809154..1809414 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU519_RS09135 (1804978) 1804978..1805448 + 471 WP_000824472.1 hypothetical protein -
KU519_RS09140 (1805789) 1805789..1806475 + 687 WP_001548082.1 thermonuclease family protein -
KU519_RS09145 (1806832) 1806832..1807032 + 201 WP_001059082.1 cold-shock protein -
KU519_RS09150 (1807528) 1807528..1807746 - 219 WP_000005886.1 hypothetical protein -
KU519_RS09155 (1807808) 1807808..1808092 - 285 WP_001004395.1 hypothetical protein -
KU519_RS09160 (1808180) 1808180..1808749 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KU519_RS09165 (1808937) 1808937..1809125 - 189 WP_000052078.1 hypothetical protein Toxin
KU519_RS09170 (1809154) 1809154..1809414 - 261 WP_001059690.1 hypothetical protein Antitoxin
KU519_RS09175 (1809755) 1809755..1809958 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU519_RS09180 (1809955) 1809955..1810191 - 237 WP_000368687.1 hypothetical protein -
KU519_RS09185 (1810416) 1810416..1810997 + 582 WP_001140686.1 histidine phosphatase family protein -
KU519_RS09190 (1811070) 1811070..1811687 - 618 WP_182055367.1 LysE/ArgO family amino acid transporter -
KU519_RS09195 (1811842) 1811842..1812336 - 495 WP_225806481.1 GNAT family N-acetyltransferase -
KU519_RS09200 (1812735) 1812735..1813157 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
KU519_RS09205 (1813305) 1813305..1814021 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T208408 WP_000052078.1 NZ_CP077888:c1809125-1808937 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208408 NZ_CP103635:1974095-1974197 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208408 WP_001059690.1 NZ_CP077888:c1809414-1809154 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208408 NZ_CP103635:c1974204-1974059 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References