208403

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 328199..328713 Replicon chromosome
Accession NZ_CP077888
Organism Staphylococcus aureus strain 334

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU519_RS01910 Protein ID WP_000581792.1
Coordinates 328199..328408 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU519_RS01915 Protein ID WP_000138932.1
Coordinates 328420..328713 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU519_RS01890 (323707) 323707..325065 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU519_RS01895 (325080) 325080..326150 - 1071 WP_000159633.1 D-alanine--D-alanine ligase -
KU519_RS01900 (326468) 326468..327670 + 1203 WP_001109935.1 FtsW/RodA/SpoVE family cell cycle protein -
KU519_RS01905 (327934) 327934..328071 - 138 WP_000828354.1 Lmo0850 family protein -
KU519_RS01910 (328199) 328199..328408 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU519_RS01915 (328420) 328420..328713 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU519_RS01920 (328879) 328879..330363 + 1485 WP_000571549.1 cardiolipin synthase -
KU519_RS01925 (330391) 330391..331038 + 648 WP_001187629.1 HD domain-containing protein -
KU519_RS01930 (331851) 331851..332723 - 873 WP_000725802.1 membrane protein insertase YidC -
KU519_RS01935 (332809) 332809..333450 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208403 WP_000581792.1 NZ_CP077888:c328408-328199 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208403 NZ_CP103634:57413-57562 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208403 WP_000138932.1 NZ_CP077888:c328713-328420 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208403 NZ_CP103634:c57369-57308 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References