Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1886456..1886970 Replicon chromosome
Accession NZ_CP077885
Organism Staphylococcus aureus strain 355

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU507_RS09695 Protein ID WP_000581792.1
Coordinates 1886456..1886665 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU507_RS09700 Protein ID WP_000138932.1
Coordinates 1886677..1886970 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU507_RS09675 (1881964) 1881964..1883322 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU507_RS09680 (1883337) 1883337..1884407 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KU507_RS09685 (1884725) 1884725..1885927 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU507_RS09690 (1886191) 1886191..1886328 - 138 WP_000828354.1 Lmo0850 family protein -
KU507_RS09695 (1886456) 1886456..1886665 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU507_RS09700 (1886677) 1886677..1886970 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU507_RS09705 (1887136) 1887136..1888620 + 1485 WP_050956558.1 cardiolipin synthase -
KU507_RS09710 (1888648) 1888648..1889295 + 648 WP_001187629.1 HD domain-containing protein -
KU507_RS09715 (1890108) 1890108..1890980 - 873 WP_000725802.1 membrane protein insertase YidC -
KU507_RS09720 (1891066) 1891066..1891707 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208389 WP_000581792.1 NZ_CP077885:c1886665-1886456 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208389 NZ_CP103633:2572372-2572548 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCGTGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208389 WP_000138932.1 NZ_CP077885:c1886970-1886677 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208389 NZ_CP103633:2572594-2573010 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References