Detailed information of TA system TA208387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1704401..1705177
• Replicon: chromosome
• Accession: NZ_CP077885
• Organism: Staphylococcus aureus strain 355

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KU507_RS08680
• Protein ID: WP_000031108.1
• Coordinates: 1704401..1704553 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KU507_RS08685
• Protein ID: WP_001251224.1
• Coordinates: 1704578..1705177 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU507_RS08665 (1700364)	1700364..1701185	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
KU507_RS08670 (1701648)	1701648..1703033	-	1386	WP_000116224.1	class II fumarate hydratase	-
KU507_RS08675 (1703229)	1703229..1703624	-	396	WP_000901021.1	hypothetical protein	-
KU507_RS08680 (1704401)	1704401..1704553	-	153	WP_000031108.1	SAS053 family protein	Toxin
KU507_RS08685 (1704578)	1704578..1705177	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KU507_RS08690 (1705336)	1705336..1705806	-	471	WP_050956565.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KU507_RS08695 (1705811)	1705811..1706938	-	1128	WP_000379978.1	tRNA epoxyqueuosine(34) reductase QueG	-
KU507_RS08700 (1707089)	1707089..1707811	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KU507_RS08705 (1707804)	1707804..1709261	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T208387 WP_000031108.1 NZ_CP077885:c1704553-1704401 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T208387 NZ_CP103633:2191377-2191480 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT208387 WP_001251224.1 NZ_CP077885:c1705177-1704578 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT208387 NZ_CP103633:c2191518-2191247 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4