Detailed information of TA system TA208381

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 573783..574260
• Replicon: chromosome
• Accession: NZ_CP077885
• Organism: Staphylococcus aureus strain 355

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q2G005
• Locus tag: KU507_RS03015
• Protein ID: WP_000052078.1
• Coordinates: 573783..573971 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: KU507_RS03020
• Protein ID: WP_001059690.1
• Coordinates: 574000..574260 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU507_RS02985 (569824)	569824..570294	+	471	WP_000824472.1	hypothetical protein	-
KU507_RS02990 (570635)	570635..571321	+	687	WP_001548082.1	thermonuclease family protein	-
KU507_RS02995 (571678)	571678..571878	+	201	WP_001059082.1	cold-shock protein	-
KU507_RS03000 (572374)	572374..572592	-	219	WP_000005886.1	hypothetical protein	-
KU507_RS03005 (572654)	572654..572938	-	285	WP_001004395.1	hypothetical protein	-
KU507_RS03010 (573026)	573026..573595	-	570	WP_050956526.1	lipoprotein N-acylation protein LnsA	-
KU507_RS03015 (573783)	573783..573971	-	189	WP_000052078.1	hypothetical protein	Toxin
KU507_RS03020 (574000)	574000..574260	-	261	WP_001059690.1	hypothetical protein	Antitoxin
KU507_RS03025 (574601)	574601..574804	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KU507_RS03030 (574801)	574801..575037	-	237	WP_000368687.1	hypothetical protein	-
KU507_RS03035 (575262)	575262..575843	+	582	WP_001140693.1	histidine phosphatase family protein	-
KU507_RS03040 (575916)	575916..576533	-	618	WP_000255561.1	LysE/ArgO family amino acid transporter	-
KU507_RS03045 (576688)	576688..577182	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
KU507_RS03050 (577581)	577581..578003	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
KU507_RS03055 (578151)	578151..578867	+	717	WP_000150017.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vWbp	528823..594874	66051

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7172.84 Da
• Isoelectric Point: 9.9971

>T208381 WP_000052078.1 NZ_CP077885:c573971-573783 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T208381 NZ_CP103633:942527-942934 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT208381 WP_001059690.1 NZ_CP077885:c574260-574000 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT208381 NZ_CP103633:942280-942546 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0D6HZ40

Antitoxin

• AlphaFold DB: A0A0E0VN56