Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1705793..1706270 Replicon chromosome
Accession NZ_CP077880
Organism Staphylococcus aureus strain 356

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag KU497_RS08740 Protein ID WP_000052078.1
Coordinates 1706082..1706270 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU497_RS08735 Protein ID WP_001059690.1
Coordinates 1705793..1706053 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU497_RS08700 (1701186) 1701186..1701902 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
KU497_RS08705 (1702050) 1702050..1702472 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
KU497_RS08710 (1702871) 1702871..1703365 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU497_RS08715 (1703520) 1703520..1704137 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
KU497_RS08720 (1704210) 1704210..1704791 - 582 WP_001140693.1 histidine phosphatase family protein -
KU497_RS08725 (1705016) 1705016..1705252 + 237 WP_000368687.1 hypothetical protein -
KU497_RS08730 (1705249) 1705249..1705452 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU497_RS08735 (1705793) 1705793..1706053 + 261 WP_001059690.1 hypothetical protein Antitoxin
KU497_RS08740 (1706082) 1706082..1706270 + 189 WP_000052078.1 hypothetical protein Toxin
KU497_RS08745 (1706458) 1706458..1707027 + 570 WP_050956526.1 lipoprotein N-acylation protein LnsA -
KU497_RS08750 (1707115) 1707115..1707399 + 285 WP_001004395.1 hypothetical protein -
KU497_RS08755 (1707461) 1707461..1707679 + 219 WP_000005886.1 hypothetical protein -
KU497_RS08760 (1708175) 1708175..1708375 - 201 WP_001059082.1 cold-shock protein -
KU497_RS08765 (1708732) 1708732..1709418 - 687 WP_001548082.1 thermonuclease family protein -
KU497_RS08770 (1709759) 1709759..1710229 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T208380 WP_000052078.1 NZ_CP077880:1706082-1706270 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208380 NZ_CP077880:1706082-1706270 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208380 WP_001059690.1 NZ_CP077880:1705793-1706053 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208380 NZ_CP077880:1705793-1706053 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References