Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 574870..575646 Replicon chromosome
Accession NZ_CP077880
Organism Staphylococcus aureus strain 356

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag KU497_RS03070 Protein ID WP_000031108.1
Coordinates 575494..575646 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag KU497_RS03065 Protein ID WP_001251224.1
Coordinates 574870..575469 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU497_RS03045 (570786) 570786..572243 + 1458 WP_000649907.1 ABC transporter permease subunit -
KU497_RS03050 (572236) 572236..572958 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
KU497_RS03055 (573109) 573109..574236 + 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
KU497_RS03060 (574241) 574241..574711 + 471 WP_050956565.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KU497_RS03065 (574870) 574870..575469 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
KU497_RS03070 (575494) 575494..575646 + 153 WP_000031108.1 SAS053 family protein Toxin
KU497_RS03075 (576423) 576423..576818 + 396 WP_000901021.1 hypothetical protein -
KU497_RS03080 (577014) 577014..578399 + 1386 WP_000116224.1 class II fumarate hydratase -
KU497_RS03085 (578862) 578862..579683 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T208374 WP_000031108.1 NZ_CP077880:575494-575646 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T208374 NZ_CP103628:c49120-48968 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT208374 WP_001251224.1 NZ_CP077880:574870-575469 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT208374 NZ_CP103628:49175-49232 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References