Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 393077..393591 Replicon chromosome
Accession NZ_CP077880
Organism Staphylococcus aureus strain 356

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU497_RS02055 Protein ID WP_000581792.1
Coordinates 393382..393591 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU497_RS02050 Protein ID WP_000138932.1
Coordinates 393077..393370 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU497_RS02030 (388340) 388340..388981 + 642 WP_000483153.1 thiamine phosphate synthase -
KU497_RS02035 (389067) 389067..389939 + 873 WP_000725802.1 membrane protein insertase YidC -
KU497_RS02040 (390752) 390752..391399 - 648 WP_001187629.1 HD domain-containing protein -
KU497_RS02045 (391427) 391427..392911 - 1485 WP_050956558.1 cardiolipin synthase -
KU497_RS02050 (393077) 393077..393370 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU497_RS02055 (393382) 393382..393591 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU497_RS02060 (393719) 393719..393856 + 138 WP_000828354.1 Lmo0850 family protein -
KU497_RS02065 (394120) 394120..395322 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU497_RS02070 (395640) 395640..396710 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KU497_RS02075 (396725) 396725..398083 + 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208372 WP_000581792.1 NZ_CP077880:393382-393591 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208372 NZ_CP103627:c73983-73834 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208372 WP_000138932.1 NZ_CP077880:393077-393370 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208372 NZ_CP103627:74027-74088 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References