Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1713869..1714346 | Replicon | chromosome |
| Accession | NZ_CP077877 | ||
| Organism | Staphylococcus aureus strain 357 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q2G005 |
| Locus tag | KU522_RS08510 | Protein ID | WP_000052078.1 |
| Coordinates | 1713869..1714057 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | KU522_RS08515 | Protein ID | WP_001059690.1 |
| Coordinates | 1714086..1714346 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU522_RS08480 (1709910) | 1709910..1710380 | + | 471 | WP_000824472.1 | hypothetical protein | - |
| KU522_RS08485 (1710721) | 1710721..1711407 | + | 687 | WP_001548082.1 | thermonuclease family protein | - |
| KU522_RS08490 (1711764) | 1711764..1711964 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| KU522_RS08495 (1712460) | 1712460..1712678 | - | 219 | WP_000005886.1 | hypothetical protein | - |
| KU522_RS08500 (1712740) | 1712740..1713024 | - | 285 | WP_001004395.1 | hypothetical protein | - |
| KU522_RS08505 (1713112) | 1713112..1713681 | - | 570 | WP_050956526.1 | lipoprotein N-acylation protein LnsA | - |
| KU522_RS08510 (1713869) | 1713869..1714057 | - | 189 | WP_000052078.1 | hypothetical protein | Toxin |
| KU522_RS08515 (1714086) | 1714086..1714346 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| KU522_RS08520 (1714687) | 1714687..1714890 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| KU522_RS08525 (1714887) | 1714887..1715123 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| KU522_RS08530 (1715348) | 1715348..1715929 | + | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
| KU522_RS08535 (1716002) | 1716002..1716619 | - | 618 | WP_000255561.1 | LysE/ArgO family amino acid transporter | - |
| KU522_RS08540 (1716774) | 1716774..1717268 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| KU522_RS08545 (1717667) | 1717667..1718089 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| KU522_RS08550 (1718237) | 1718237..1718953 | + | 717 | WP_000150017.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | vWbp | 1668909..1734960 | 66051 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7172.84 Da Isoelectric Point: 9.9971
>T208357 WP_000052078.1 NZ_CP077877:c1714057-1713869 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T208357 NZ_CP103626:724375-724671 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT208357 WP_001059690.1 NZ_CP077877:c1714346-1714086 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT208357 NZ_CP103626:724673-725068 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D6HZ40 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |