Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2192911..2193425 Replicon chromosome
Accession NZ_CP077870
Organism Staphylococcus aureus strain 360

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU523_RS11015 Protein ID WP_000581792.1
Coordinates 2192911..2193120 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU523_RS11020 Protein ID WP_000138932.1
Coordinates 2193132..2193425 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU523_RS10995 (2188419) 2188419..2189777 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU523_RS11000 (2189792) 2189792..2190862 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KU523_RS11005 (2191180) 2191180..2192382 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU523_RS11010 (2192646) 2192646..2192783 - 138 WP_000828354.1 Lmo0850 family protein -
KU523_RS11015 (2192911) 2192911..2193120 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU523_RS11020 (2193132) 2193132..2193425 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU523_RS11025 (2193591) 2193591..2195075 + 1485 WP_050956558.1 cardiolipin synthase -
KU523_RS11030 (2195103) 2195103..2195750 + 648 WP_001187629.1 HD domain-containing protein -
KU523_RS11035 (2196563) 2196563..2197435 - 873 WP_000725802.1 membrane protein insertase YidC -
KU523_RS11040 (2197521) 2197521..2198162 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208327 WP_000581792.1 NZ_CP077870:c2193120-2192911 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208327 NZ_CP103621:3958212-3958430 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208327 WP_000138932.1 NZ_CP077870:c2193425-2193132 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208327 NZ_CP103621:3957811-3958185 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References