208319

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 879727..880204 Replicon chromosome
Accession NZ_CP077870
Organism Staphylococcus aureus strain 360

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag KU523_RS04330 Protein ID WP_000052078.1
Coordinates 879727..879915 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU523_RS04335 Protein ID WP_001059690.1
Coordinates 879944..880204 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU523_RS04300 (875768) 875768..876238 + 471 WP_000824472.1 hypothetical protein -
KU523_RS04305 (876579) 876579..877265 + 687 WP_001548082.1 thermonuclease family protein -
KU523_RS04310 (877622) 877622..877822 + 201 WP_001059082.1 cold-shock protein -
KU523_RS04315 (878318) 878318..878536 - 219 WP_000005886.1 hypothetical protein -
KU523_RS04320 (878598) 878598..878882 - 285 WP_001004395.1 hypothetical protein -
KU523_RS04325 (878970) 878970..879539 - 570 WP_050956526.1 lipoprotein N-acylation protein LnsA -
KU523_RS04330 (879727) 879727..879915 - 189 WP_000052078.1 hypothetical protein Toxin
KU523_RS04335 (879944) 879944..880204 - 261 WP_001059690.1 hypothetical protein Antitoxin
KU523_RS04340 (880545) 880545..880748 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU523_RS04345 (880745) 880745..880981 - 237 WP_000368687.1 hypothetical protein -
KU523_RS04350 (881206) 881206..881787 + 582 WP_001140693.1 histidine phosphatase family protein -
KU523_RS04355 (881860) 881860..882477 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
KU523_RS04360 (882632) 882632..883126 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU523_RS04365 (883525) 883525..883947 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
KU523_RS04370 (884095) 884095..884811 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vWbp 834767..900818 66051


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T208319 WP_000052078.1 NZ_CP077870:c879915-879727 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208319 NZ_CP103619:53921-54403 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208319 WP_001059690.1 NZ_CP077870:c880204-879944 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208319 NZ_CP103619:53667-53933 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References