208313

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1869163..1869677 Replicon chromosome
Accession NZ_CP077869
Organism Staphylococcus aureus strain 365

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU517_RS09340 Protein ID WP_000581792.1
Coordinates 1869163..1869372 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag KU517_RS09345 Protein ID WP_000138934.1
Coordinates 1869384..1869677 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU517_RS09320 (1864671) 1864671..1866029 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU517_RS09325 (1866044) 1866044..1867114 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU517_RS09330 (1867432) 1867432..1868634 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU517_RS09335 (1868898) 1868898..1869035 - 138 WP_000828354.1 Lmo0850 family protein -
KU517_RS09340 (1869163) 1869163..1869372 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU517_RS09345 (1869384) 1869384..1869677 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU517_RS09350 (1869843) 1869843..1871327 + 1485 WP_000571549.1 cardiolipin synthase -
KU517_RS09355 (1871355) 1871355..1872002 + 648 WP_001187610.1 HD domain-containing protein -
KU517_RS09360 (1872817) 1872817..1873689 - 873 WP_000725802.1 membrane protein insertase YidC -
KU517_RS09365 (1873775) 1873775..1874416 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208313 WP_000581792.1 NZ_CP077869:c1869372-1869163 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208313 NZ_CP103618:4093711-4093929 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT208313 WP_000138934.1 NZ_CP077869:c1869677-1869384 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208313 NZ_CP103618:4093310-4093684 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References