Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 626247..626779 | Replicon | chromosome |
| Accession | NZ_CP077869 | ||
| Organism | Staphylococcus aureus strain 365 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | Q93CD4 |
| Locus tag | KU517_RS03130 | Protein ID | WP_001103942.1 |
| Coordinates | 626459..626779 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | - |
| Locus tag | KU517_RS03125 | Protein ID | WP_001058486.1 |
| Coordinates | 626247..626456 (+) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU517_RS03080 (621266) | 621266..622486 | - | 1221 | WP_225805722.1 | site-specific integrase | - |
| KU517_RS03085 (622575) | 622575..623303 | - | 729 | WP_000733774.1 | staphylococcal enterotoxin type K | - |
| KU517_RS03090 (623327) | 623327..624055 | - | 729 | WP_001033316.1 | staphylococcal enterotoxin type Q | - |
| KU517_RS03095 (624125) | 624125..624556 | - | 432 | WP_001228759.1 | hypothetical protein | - |
| KU517_RS03100 (624573) | 624573..625031 | - | 459 | WP_000281657.1 | ImmA/IrrE family metallo-endopeptidase | - |
| KU517_RS03105 (625043) | 625043..625375 | - | 333 | WP_001260004.1 | helix-turn-helix transcriptional regulator | - |
| KU517_RS03110 (625568) | 625568..625831 | + | 264 | WP_000243851.1 | helix-turn-helix transcriptional regulator | - |
| KU517_RS03115 (625824) | 625824..626096 | + | 273 | WP_000091731.1 | helix-turn-helix domain-containing protein | - |
| KU517_RS03120 (626108) | 626108..626254 | + | 147 | WP_000784875.1 | hypothetical protein | - |
| KU517_RS03125 (626247) | 626247..626456 | + | 210 | WP_001058486.1 | hypothetical protein | Antitoxin |
| KU517_RS03130 (626459) | 626459..626779 | + | 321 | WP_001103942.1 | DUF1474 family protein | Toxin |
| KU517_RS03135 (626843) | 626843..627712 | + | 870 | WP_001002732.1 | primase alpha helix C-terminal domain-containing protein | - |
| KU517_RS03140 (627729) | 627729..629198 | + | 1470 | WP_000390454.1 | virulence-associated E family protein | - |
| KU517_RS03145 (629484) | 629484..629846 | + | 363 | WP_001039168.1 | hypothetical protein | - |
| KU517_RS03150 (629848) | 629848..630132 | + | 285 | WP_000998181.1 | hypothetical protein | - |
| KU517_RS03155 (630129) | 630129..630770 | + | 642 | WP_001019764.1 | hypothetical protein | - |
| KU517_RS03160 (631287) | 631287..631628 | + | 342 | WP_001190615.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | selk / selq / seb | 603232..636579 | 33347 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12694.22 Da Isoelectric Point: 4.7419
>T208307 WP_001103942.1 NZ_CP077869:626459-626779 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
Download Length: 321 bp
>T208307 NZ_CP103618:323354-323722 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8252.31 Da Isoelectric Point: 4.3718
>AT208307 WP_001058486.1 NZ_CP077869:626247-626456 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT208307 NZ_CP103618:323136-323357 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|