Detailed information of TA system TA208305

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2106906..2107383
• Replicon: chromosome
• Accession: NZ_CP077868
• Organism: Staphylococcus aureus strain 366

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KU506_RS10400
• Protein ID: WP_000052076.1
• Coordinates: 2107195..2107383 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: KU506_RS10395
• Protein ID: WP_001059690.1
• Coordinates: 2106906..2107166 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU506_RS10360 (2102299)	2102299..2103015	-	717	WP_000150029.1	type I 3-dehydroquinate dehydratase	-
KU506_RS10365 (2103163)	2103163..2103585	+	423	WP_000974455.1	organic hydroperoxide resistance protein	-
KU506_RS10370 (2103984)	2103984..2104478	+	495	WP_000569881.1	GNAT family N-acetyltransferase	-
KU506_RS10375 (2104634)	2104634..2105251	+	618	WP_000255554.1	LysE/ArgO family amino acid transporter	-
KU506_RS10380 (2105324)	2105324..2105905	-	582	WP_001140697.1	histidine phosphatase family protein	-
KU506_RS10385 (2106129)	2106129..2106365	+	237	WP_000368687.1	hypothetical protein	-
KU506_RS10390 (2106362)	2106362..2106565	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KU506_RS10395 (2106906)	2106906..2107166	+	261	WP_001059690.1	hypothetical protein	Antitoxin
KU506_RS10400 (2107195)	2107195..2107383	+	189	WP_000052076.1	hypothetical protein	Toxin
KU506_RS10405 (2107571)	2107571..2108140	+	570	WP_001106657.1	lipoprotein N-acylation protein LnsA	-
KU506_RS10410 (2108228)	2108228..2108512	+	285	WP_001004397.1	hypothetical protein	-
KU506_RS10415 (2108574)	2108574..2108792	+	219	WP_000005888.1	hypothetical protein	-
KU506_RS10420 (2109291)	2109291..2109491	-	201	WP_001059082.1	cold-shock protein	-
KU506_RS10425 (2109848)	2109848..2110534	-	687	WP_001823812.1	thermonuclease family protein	-
KU506_RS10430 (2110875)	2110875..2111345	-	471	WP_000824462.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	seb / selq / selk / vWbp	2079356..2121537	42181

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-112)

Antitoxin

• Predicted DNA-binding protein, ribbon-helix-helix domain (16-47)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T208305 WP_000052076.1 NZ_CP077868:2107195-2107383 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T208305 NZ_CP103614:c5275354-5274971 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT208305 WP_001059690.1 NZ_CP077868:2106906-2107166 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT208305 NZ_CP103614:c5275596-5275354 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56