Detailed information of TA system TA208304

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2089156..2089688
• Replicon: chromosome
• Accession: NZ_CP077868
• Organism: Staphylococcus aureus strain 366

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: KU506_RS10255
• Protein ID: WP_001103942.1
• Coordinates: 2089156..2089476 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: KU506_RS10260
• Protein ID: WP_001058486.1
• Coordinates: 2089479..2089688 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU506_RS10225 (2084307)	2084307..2084648	-	342	WP_001190615.1	hypothetical protein	-
KU506_RS10230 (2085165)	2085165..2085806	-	642	WP_001019764.1	hypothetical protein	-
KU506_RS10235 (2085803)	2085803..2086087	-	285	WP_000998181.1	hypothetical protein	-
KU506_RS10240 (2086089)	2086089..2086451	-	363	WP_001039168.1	hypothetical protein	-
KU506_RS10245 (2086737)	2086737..2088206	-	1470	WP_000390454.1	virulence-associated E family protein	-
KU506_RS10250 (2088223)	2088223..2089092	-	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
KU506_RS10255 (2089156)	2089156..2089476	-	321	WP_001103942.1	DUF1474 family protein	Toxin
KU506_RS10260 (2089479)	2089479..2089688	-	210	WP_001058486.1	hypothetical protein	Antitoxin
KU506_RS10265 (2089681)	2089681..2089827	-	147	WP_000784875.1	hypothetical protein	-
KU506_RS10270 (2089839)	2089839..2090111	-	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
KU506_RS10275 (2090104)	2090104..2090367	-	264	WP_000243851.1	helix-turn-helix transcriptional regulator	-
KU506_RS10280 (2090560)	2090560..2090892	+	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
KU506_RS10285 (2090904)	2090904..2091362	+	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
KU506_RS10290 (2091379)	2091379..2091810	+	432	WP_001228759.1	hypothetical protein	-
KU506_RS10295 (2091880)	2091880..2092608	+	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
KU506_RS10300 (2092632)	2092632..2093360	+	729	WP_000733774.1	staphylococcal enterotoxin type K	-
KU506_RS10305 (2093449)	2093449..2094669	+	1221	WP_225805722.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	seb / selq / selk / vWbp	2079356..2121537	42181

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T208304 WP_001103942.1 NZ_CP077868:c2089476-2089156 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T208304 NZ_CP103614:c4922101-4921184 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT208304 WP_001058486.1 NZ_CP077868:c2089688-2089479 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT208304 NZ_CP103614:c4922865-4922107 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4