Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 866198..866727 Replicon chromosome
Accession NZ_CP077868
Organism Staphylococcus aureus strain 366

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KU506_RS04155 Protein ID WP_000621175.1
Coordinates 866365..866727 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag KU506_RS04150 Protein ID WP_000948331.1
Coordinates 866198..866368 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU506_RS04120 (861234) 861234..861794 + 561 WP_001092405.1 K(+)-transporting ATPase subunit C -
KU506_RS04125 (862003) 862003..862482 + 480 WP_001287083.1 hypothetical protein -
KU506_RS04130 (862475) 862475..864058 + 1584 WP_001294642.1 PH domain-containing protein -
KU506_RS04135 (864045) 864045..864536 + 492 WP_001205915.1 PH domain-containing protein -
KU506_RS04140 (864540) 864540..864899 + 360 WP_000581194.1 holo-ACP synthase -
KU506_RS04145 (864965) 864965..866113 + 1149 WP_001280702.1 alanine racemase -
KU506_RS04150 (866198) 866198..866368 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KU506_RS04155 (866365) 866365..866727 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KU506_RS04160 (867076) 867076..868077 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
KU506_RS04165 (868196) 868196..868522 + 327 WP_001052491.1 anti-sigma factor antagonist -
KU506_RS04170 (868524) 868524..869003 + 480 WP_001190825.1 anti-sigma B factor RsbW -
KU506_RS04175 (868978) 868978..869748 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T208299 WP_000621175.1 NZ_CP077868:866365-866727 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T208299 NZ_CP103614:1900618-1900720 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT208299 WP_000948331.1 NZ_CP077868:866198-866368 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT208299 NZ_CP103614:c1900727-1900582 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References