Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 846473..846987 Replicon chromosome
Accession NZ_CP077868
Organism Staphylococcus aureus strain 366

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU506_RS04065 Protein ID WP_000581792.1
Coordinates 846778..846987 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag KU506_RS04060 Protein ID WP_000138934.1
Coordinates 846473..846766 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU506_RS04040 (841734) 841734..842375 + 642 WP_000483147.1 thiamine phosphate synthase -
KU506_RS04045 (842461) 842461..843333 + 873 WP_000725802.1 membrane protein insertase YidC -
KU506_RS04050 (844148) 844148..844795 - 648 WP_001187610.1 HD domain-containing protein -
KU506_RS04055 (844823) 844823..846307 - 1485 WP_000571549.1 cardiolipin synthase -
KU506_RS04060 (846473) 846473..846766 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU506_RS04065 (846778) 846778..846987 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU506_RS04070 (847115) 847115..847252 + 138 WP_000828354.1 Lmo0850 family protein -
KU506_RS04075 (847516) 847516..848718 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU506_RS04080 (849036) 849036..850106 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU506_RS04085 (850121) 850121..851479 + 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208298 WP_000581792.1 NZ_CP077868:846778-846987 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208298 NZ_CP103614:795693-796103 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT208298 WP_000138934.1 NZ_CP077868:846473-846766 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208298 NZ_CP103614:795446-795712 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References