Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2503036..2503812 Replicon chromosome
Accession NZ_CP077867
Organism Staphylococcus aureus strain 367

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag KU500_RS12255 Protein ID WP_000031108.1
Coordinates 2503660..2503812 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag KU500_RS12250 Protein ID WP_001251218.1
Coordinates 2503036..2503635 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU500_RS12225 (2498205) 2498205..2498693 + 489 Protein_2377 PTS sugar transporter subunit IIC -
KU500_RS12230 (2498952) 2498952..2500409 + 1458 WP_000649908.1 ABC transporter permease subunit -
KU500_RS12235 (2500402) 2500402..2501124 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
KU500_RS12240 (2501275) 2501275..2502402 + 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
KU500_RS12245 (2502407) 2502407..2502877 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KU500_RS12250 (2503036) 2503036..2503635 + 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
KU500_RS12255 (2503660) 2503660..2503812 + 153 WP_000031108.1 SAS053 family protein Toxin
KU500_RS12260 (2504419) 2504419..2504814 + 396 WP_000901022.1 hypothetical protein -
KU500_RS12265 (2505010) 2505010..2506395 + 1386 WP_000116233.1 class II fumarate hydratase -
KU500_RS12270 (2506860) 2506860..2507681 - 822 WP_000669384.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T208290 WP_000031108.1 NZ_CP077867:2503660-2503812 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T208290 NZ_CP103611:c3002303-3002200 [Enterobacter cloacae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT208290 WP_001251218.1 NZ_CP077867:2503036-2503635 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT208290 NZ_CP103611:3002187-3002338 [Enterobacter cloacae]
CTTTCAATCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References