Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2366616..2367447 Replicon chromosome
Accession NC_004431
Organism Escherichia coli CFT073

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag C_RS12010 Protein ID WP_000854814.1
Coordinates 2367073..2367447 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag C_RS12005 Protein ID WP_001285586.1
Coordinates 2366616..2366984 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C_RS11970 2361833..2362903 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
C_RS11975 2363039..2363716 + 678 WP_001362823.1 hypothetical protein -
C_RS11980 2363732..2364142 + 411 WP_000846704.1 hypothetical protein -
C_RS11985 2364363..2365184 + 822 WP_001234569.1 DUF945 domain-containing protein -
C_RS11990 2365275..2365760 + 486 WP_000213703.1 antirestriction protein -
C_RS11995 2365776..2366252 + 477 WP_001351157.1 RadC family protein -
C_RS12000 2366321..2366542 + 222 WP_000692323.1 DUF987 domain-containing protein -
C_RS12005 2366616..2366984 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
C_RS12010 2367073..2367447 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
C_RS12015 2367444..2367638 + 195 WP_000988601.1 hypothetical protein -
C_RS29725 2367651..2367764 + 114 WP_001161660.1 DUF957 domain-containing protein -
C_RS29325 2368053..2368226 - 174 WP_032082634.1 transposase domain-containing protein -
C_RS29330 2368253..2368435 + 183 WP_001016348.1 hypothetical protein -
C_RS12030 2368536..2368865 - 330 WP_000450409.1 DUF496 family protein -
C_RS12035 2369037..2370095 - 1059 WP_001200890.1 FUSC family protein -
C_RS12040 2370293..2370766 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
C_RS12045 2370885..2372051 - 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T20829 WP_000854814.1 NC_004431:2367073-2367447 [Escherichia coli CFT073]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T20829 NC_004431:2367073-2367447 [Escherichia coli CFT073]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT20829 WP_001285586.1 NC_004431:2366616-2366984 [Escherichia coli CFT073]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT20829 NC_004431:2366616-2366984 [Escherichia coli CFT073]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References