208288

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2332100..2332614 Replicon chromosome
Accession NZ_CP077867
Organism Staphylococcus aureus strain 367

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU500_RS11295 Protein ID WP_000581792.1
Coordinates 2332405..2332614 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag KU500_RS11290 Protein ID WP_000138934.1
Coordinates 2332100..2332393 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU500_RS11270 (2327361) 2327361..2328002 + 642 WP_000483147.1 thiamine phosphate synthase -
KU500_RS11275 (2328088) 2328088..2328960 + 873 WP_000725802.1 membrane protein insertase YidC -
KU500_RS11280 (2329775) 2329775..2330422 - 648 WP_001187610.1 HD domain-containing protein -
KU500_RS11285 (2330450) 2330450..2331934 - 1485 WP_000571549.1 cardiolipin synthase -
KU500_RS11290 (2332100) 2332100..2332393 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU500_RS11295 (2332405) 2332405..2332614 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU500_RS11300 (2332742) 2332742..2332879 + 138 WP_000828354.1 Lmo0850 family protein -
KU500_RS11305 (2333143) 2333143..2334345 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU500_RS11310 (2334663) 2334663..2335733 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU500_RS11315 (2335748) 2335748..2337106 + 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208288 WP_000581792.1 NZ_CP077867:2332405-2332614 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208288 NZ_CP103611:592475-592762 [Enterobacter cloacae]
ATGCCAACGGAGTATGAGTGGGATAGCGATAAGGCGAAAAGTAACCAGCAAAAACATGGCATACGCTTTGAGGATGCGGT
TCTGGTTTTCGACGATCCTTATCATTTGTCTGTTCAGGATCGCTATGAGAACGGTGAGTTTCGCTGGCAAACCATCGGCC
TTGTGCAAGGCGTCATTGTTATCCTGGTCGCACATACGGTACGTTTCGAAAGCGGAGGCGAAATTATTCGTATCATTAGC
GCACGTAAGGCGGACCGTAAAGAGAGGAACCGTTATGAGCATCGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT208288 WP_000138934.1 NZ_CP077867:2332100-2332393 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208288 NZ_CP103611:592749-593051 [Enterobacter cloacae]
ATGAGCATCGTTAAACATAAACGAGGTAGTTCGCCTGAGGTTAGCGCTCGTCGTGACGCTGAGCTAAAAGCATTAGCTGA
AAAAACAGAAGCAGAAATCGATTACAGCGATATTCCTGCCACGGACGATAAACAGTGGTCCGGGGCGGTGCGAGGGAAGT
TCTATCGGCCACTTAAAACGCAGGCATCTGTACGCATTGACGCCGACGTGATGGAGTGGCTGAAACGGCCTGGAAAGGGT
TACCAGACGCGGCTAAACGCCATATTGCGTGAAGCGATGCTGCGCGATCAAAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References