Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 806143..806620 Replicon chromosome
Accession NZ_CP077867
Organism Staphylococcus aureus strain 367

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU500_RS03905 Protein ID WP_000052076.1
Coordinates 806432..806620 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU500_RS03900 Protein ID WP_001059690.1
Coordinates 806143..806403 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU500_RS03865 (801536) 801536..802252 - 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -
KU500_RS03870 (802400) 802400..802822 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
KU500_RS03875 (803221) 803221..803715 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
KU500_RS03880 (803871) 803871..804488 + 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
KU500_RS03885 (804561) 804561..805142 - 582 WP_001140697.1 histidine phosphatase family protein -
KU500_RS03890 (805366) 805366..805602 + 237 WP_000368687.1 hypothetical protein -
KU500_RS03895 (805599) 805599..805802 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU500_RS03900 (806143) 806143..806403 + 261 WP_001059690.1 hypothetical protein Antitoxin
KU500_RS03905 (806432) 806432..806620 + 189 WP_000052076.1 hypothetical protein Toxin
KU500_RS03910 (806808) 806808..807377 + 570 WP_001106657.1 lipoprotein N-acylation protein LnsA -
KU500_RS03915 (807465) 807465..807749 + 285 WP_001004397.1 hypothetical protein -
KU500_RS03920 (807811) 807811..808029 + 219 WP_000005888.1 hypothetical protein -
KU500_RS03925 (808528) 808528..808728 - 201 WP_001059082.1 cold-shock protein -
KU500_RS03930 (809085) 809085..809771 - 687 WP_001823812.1 thermonuclease family protein -
KU500_RS03935 (810112) 810112..810582 - 471 WP_000824462.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - seb / selq / selk / vWbp 778593..820774 42181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208280 WP_000052076.1 NZ_CP077867:806432-806620 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208280 NZ_CP077867:806432-806620 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208280 WP_001059690.1 NZ_CP077867:806143-806403 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208280 NZ_CP077867:806143-806403 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References