Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 788393..788925 | Replicon | chromosome |
| Accession | NZ_CP077867 | ||
| Organism | Staphylococcus aureus strain 367 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | Q93CD4 |
| Locus tag | KU500_RS03760 | Protein ID | WP_001103942.1 |
| Coordinates | 788393..788713 (-) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | - |
| Locus tag | KU500_RS03765 | Protein ID | WP_001058486.1 |
| Coordinates | 788716..788925 (-) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU500_RS03730 (783544) | 783544..783885 | - | 342 | WP_001190615.1 | hypothetical protein | - |
| KU500_RS03735 (784402) | 784402..785043 | - | 642 | WP_001019764.1 | hypothetical protein | - |
| KU500_RS03740 (785040) | 785040..785324 | - | 285 | WP_000998181.1 | hypothetical protein | - |
| KU500_RS03745 (785326) | 785326..785688 | - | 363 | WP_001039168.1 | hypothetical protein | - |
| KU500_RS03750 (785974) | 785974..787443 | - | 1470 | WP_000390454.1 | virulence-associated E family protein | - |
| KU500_RS03755 (787460) | 787460..788329 | - | 870 | WP_001002732.1 | primase alpha helix C-terminal domain-containing protein | - |
| KU500_RS03760 (788393) | 788393..788713 | - | 321 | WP_001103942.1 | DUF1474 family protein | Toxin |
| KU500_RS03765 (788716) | 788716..788925 | - | 210 | WP_001058486.1 | hypothetical protein | Antitoxin |
| KU500_RS03770 (788918) | 788918..789064 | - | 147 | WP_000784875.1 | hypothetical protein | - |
| KU500_RS03775 (789076) | 789076..789348 | - | 273 | WP_000091731.1 | helix-turn-helix domain-containing protein | - |
| KU500_RS03780 (789341) | 789341..789604 | - | 264 | WP_000243851.1 | helix-turn-helix transcriptional regulator | - |
| KU500_RS03785 (789797) | 789797..790129 | + | 333 | WP_001260004.1 | helix-turn-helix transcriptional regulator | - |
| KU500_RS03790 (790141) | 790141..790599 | + | 459 | WP_000281657.1 | ImmA/IrrE family metallo-endopeptidase | - |
| KU500_RS03795 (790616) | 790616..791047 | + | 432 | WP_001228759.1 | hypothetical protein | - |
| KU500_RS03800 (791117) | 791117..791845 | + | 729 | WP_001033316.1 | staphylococcal enterotoxin type Q | - |
| KU500_RS03805 (791869) | 791869..792597 | + | 729 | WP_000733774.1 | staphylococcal enterotoxin type K | - |
| KU500_RS03810 (792686) | 792686..793906 | + | 1221 | WP_225805722.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | seb / selq / selk / vWbp | 778593..820774 | 42181 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12694.22 Da Isoelectric Point: 4.7419
>T208279 WP_001103942.1 NZ_CP077867:c788713-788393 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
Download Length: 321 bp
>T208279 NZ_CP103609:c4645643-4645413 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8252.31 Da Isoelectric Point: 4.3718
>AT208279 WP_001058486.1 NZ_CP077867:c788925-788716 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT208279 NZ_CP103609:c4645416-4645057 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|