Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 2224670..2225202 | Replicon | chromosome |
| Accession | NZ_CP077865 | ||
| Organism | Staphylococcus aureus strain 370 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | Q93CD4 |
| Locus tag | KU528_RS10965 | Protein ID | WP_001103942.1 |
| Coordinates | 2224882..2225202 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | - |
| Locus tag | KU528_RS10960 | Protein ID | WP_001058486.1 |
| Coordinates | 2224670..2224879 (+) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU528_RS10915 (2219689) | 2219689..2220909 | - | 1221 | WP_225805722.1 | site-specific integrase | - |
| KU528_RS10920 (2220998) | 2220998..2221726 | - | 729 | WP_000733774.1 | staphylococcal enterotoxin type K | - |
| KU528_RS10925 (2221750) | 2221750..2222478 | - | 729 | WP_001033316.1 | staphylococcal enterotoxin type Q | - |
| KU528_RS10930 (2222548) | 2222548..2222979 | - | 432 | WP_001228759.1 | hypothetical protein | - |
| KU528_RS10935 (2222996) | 2222996..2223454 | - | 459 | WP_000281657.1 | ImmA/IrrE family metallo-endopeptidase | - |
| KU528_RS10940 (2223466) | 2223466..2223798 | - | 333 | WP_001260004.1 | helix-turn-helix transcriptional regulator | - |
| KU528_RS10945 (2223991) | 2223991..2224254 | + | 264 | WP_000243851.1 | helix-turn-helix transcriptional regulator | - |
| KU528_RS10950 (2224247) | 2224247..2224519 | + | 273 | WP_000091731.1 | helix-turn-helix domain-containing protein | - |
| KU528_RS10955 (2224531) | 2224531..2224677 | + | 147 | WP_000784875.1 | hypothetical protein | - |
| KU528_RS10960 (2224670) | 2224670..2224879 | + | 210 | WP_001058486.1 | hypothetical protein | Antitoxin |
| KU528_RS10965 (2224882) | 2224882..2225202 | + | 321 | WP_001103942.1 | DUF1474 family protein | Toxin |
| KU528_RS10970 (2225266) | 2225266..2226135 | + | 870 | WP_001002732.1 | primase alpha helix C-terminal domain-containing protein | - |
| KU528_RS10975 (2226152) | 2226152..2227621 | + | 1470 | WP_000390454.1 | virulence-associated E family protein | - |
| KU528_RS10980 (2227907) | 2227907..2228269 | + | 363 | WP_001039168.1 | hypothetical protein | - |
| KU528_RS10985 (2228271) | 2228271..2228555 | + | 285 | WP_000998181.1 | hypothetical protein | - |
| KU528_RS10990 (2228552) | 2228552..2229193 | + | 642 | WP_001019764.1 | hypothetical protein | - |
| KU528_RS10995 (2229710) | 2229710..2230051 | + | 342 | WP_001190615.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | selk / selq / seb | 2201655..2235002 | 33347 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12694.22 Da Isoelectric Point: 4.7419
>T208275 WP_001103942.1 NZ_CP077865:2224882-2225202 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
Download Length: 321 bp
>T208275 NZ_CP103609:c3542859-3542461 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8252.31 Da Isoelectric Point: 4.3718
>AT208275 WP_001058486.1 NZ_CP077865:2224670-2224879 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT208275 NZ_CP103609:c3543086-3542859 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|