Detailed information of TA system TA208274

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2206975..2207452
• Replicon: chromosome
• Accession: NZ_CP077865
• Organism: Staphylococcus aureus strain 370

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KU528_RS10820
• Protein ID: WP_000052076.1
• Coordinates: 2206975..2207163 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: KU528_RS10825
• Protein ID: WP_001059690.1
• Coordinates: 2207192..2207452 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU528_RS10790 (2203013)	2203013..2203483	+	471	WP_000824462.1	hypothetical protein	-
KU528_RS10795 (2203824)	2203824..2204510	+	687	WP_001823812.1	thermonuclease family protein	-
KU528_RS10800 (2204867)	2204867..2205067	+	201	WP_001059082.1	cold-shock protein	-
KU528_RS10805 (2205566)	2205566..2205784	-	219	WP_000005888.1	hypothetical protein	-
KU528_RS10810 (2205846)	2205846..2206130	-	285	WP_001004397.1	hypothetical protein	-
KU528_RS10815 (2206218)	2206218..2206787	-	570	WP_001106657.1	lipoprotein N-acylation protein LnsA	-
KU528_RS10820 (2206975)	2206975..2207163	-	189	WP_000052076.1	hypothetical protein	Toxin
KU528_RS10825 (2207192)	2207192..2207452	-	261	WP_001059690.1	hypothetical protein	Antitoxin
KU528_RS10830 (2207793)	2207793..2207996	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KU528_RS10835 (2207993)	2207993..2208229	-	237	WP_000368687.1	hypothetical protein	-
KU528_RS10840 (2208453)	2208453..2209034	+	582	WP_001140697.1	histidine phosphatase family protein	-
KU528_RS10845 (2209107)	2209107..2209724	-	618	WP_000255554.1	LysE/ArgO family amino acid transporter	-
KU528_RS10850 (2209880)	2209880..2210374	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
KU528_RS10855 (2210773)	2210773..2211195	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
KU528_RS10860 (2211343)	2211343..2212059	+	717	WP_000150029.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	2201655..2235002	33347

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (5-84)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T208274 WP_000052076.1 NZ_CP077865:c2207163-2206975 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T208274 NZ_CP103609:c3038170-3037919 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT208274 WP_001059690.1 NZ_CP077865:c2207452-2207192 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT208274 NZ_CP103609:c3037922-3037668 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56