Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 710859..711373 Replicon chromosome
Accession NZ_CP077865
Organism Staphylococcus aureus strain 370

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU528_RS03625 Protein ID WP_000581792.1
Coordinates 710859..711068 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag KU528_RS03630 Protein ID WP_000138934.1
Coordinates 711080..711373 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU528_RS03605 (706367) 706367..707725 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU528_RS03610 (707740) 707740..708810 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU528_RS03615 (709128) 709128..710330 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU528_RS03620 (710594) 710594..710731 - 138 WP_000828354.1 Lmo0850 family protein -
KU528_RS03625 (710859) 710859..711068 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU528_RS03630 (711080) 711080..711373 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU528_RS03635 (711539) 711539..713023 + 1485 WP_000571549.1 cardiolipin synthase -
KU528_RS03640 (713051) 713051..713698 + 648 WP_001187610.1 HD domain-containing protein -
KU528_RS03645 (714513) 714513..715385 - 873 WP_000725802.1 membrane protein insertase YidC -
KU528_RS03650 (715471) 715471..716112 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208268 WP_000581792.1 NZ_CP077865:c711068-710859 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208268 NZ_CP103609:c2204835-2204728 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT208268 WP_000138934.1 NZ_CP077865:c711373-711080 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208268 NZ_CP103609:2204885-2204948 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References