Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 539447..540223 Replicon chromosome
Accession NZ_CP077865
Organism Staphylococcus aureus strain 370

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag KU528_RS02655 Protein ID WP_000031108.1
Coordinates 539447..539599 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag KU528_RS02660 Protein ID WP_001251218.1
Coordinates 539624..540223 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU528_RS02640 (535578) 535578..536399 + 822 WP_000669384.1 RluA family pseudouridine synthase -
KU528_RS02645 (536864) 536864..538249 - 1386 WP_000116233.1 class II fumarate hydratase -
KU528_RS02650 (538445) 538445..538840 - 396 WP_000901022.1 hypothetical protein -
KU528_RS02655 (539447) 539447..539599 - 153 WP_000031108.1 SAS053 family protein Toxin
KU528_RS02660 (539624) 539624..540223 - 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
KU528_RS02665 (540382) 540382..540852 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KU528_RS02670 (540857) 540857..541984 - 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
KU528_RS02675 (542135) 542135..542857 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
KU528_RS02680 (542850) 542850..544307 - 1458 WP_000649908.1 ABC transporter permease subunit -
KU528_RS02685 (544566) 544566..545054 - 489 Protein_526 PTS sugar transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T208266 WP_000031108.1 NZ_CP077865:c539599-539447 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T208266 NZ_CP103609:c1422052-1421834 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT208266 WP_001251218.1 NZ_CP077865:c540223-539624 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT208266 NZ_CP103609:c1422452-1422078 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References