Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2346549..2347325 Replicon chromosome
Accession NZ_CP077863
Organism Staphylococcus aureus strain 371

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag KU524_RS11395 Protein ID WP_000031108.1
Coordinates 2347173..2347325 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag KU524_RS11390 Protein ID WP_001251218.1
Coordinates 2346549..2347148 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU524_RS11365 (2341718) 2341718..2342206 + 489 Protein_2202 PTS sugar transporter subunit IIC -
KU524_RS11370 (2342465) 2342465..2343922 + 1458 WP_000649908.1 ABC transporter permease subunit -
KU524_RS11375 (2343915) 2343915..2344637 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
KU524_RS11380 (2344788) 2344788..2345915 + 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
KU524_RS11385 (2345920) 2345920..2346390 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KU524_RS11390 (2346549) 2346549..2347148 + 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
KU524_RS11395 (2347173) 2347173..2347325 + 153 WP_000031108.1 SAS053 family protein Toxin
KU524_RS11400 (2347932) 2347932..2348327 + 396 WP_000901022.1 hypothetical protein -
KU524_RS11405 (2348523) 2348523..2349908 + 1386 WP_000116233.1 class II fumarate hydratase -
KU524_RS11410 (2350373) 2350373..2351194 - 822 WP_000669384.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T208259 WP_000031108.1 NZ_CP077863:2347173-2347325 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T208259 NZ_CP103607:17717-18127 [Klebsiella pneumoniae]
GTGAACAAAATGTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGGGGTCACCGCATTGTGGTTTCGGCCATCACCTGGGCCGAAGTGTCACTGGCATCACAGGAAG
CAGGACCAGCCGCACAGAAGCTGGCTGACGCCTTCGCTGCCCGCCTTGATGCCATCCTGCCCTGGGACCGTACCGCGGTG
GACGCGACCACGGAAATTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGGCCGAACGACACGGCGATCGCCGGGCA
CGCCATCGCCGCCGGTGCCGTGCTGGTGACCAATAATGTGCGGGAATTTGAGCGGGTGCCGGGTCTGGTGCTGGAAGACT
GGGTAAGATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT208259 WP_001251218.1 NZ_CP077863:2346549-2347148 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT208259 NZ_CP103607:17490-17720 [Klebsiella pneumoniae]
ATGAGAACCGTATCTATTTTCAAAAACGGCAACAACCGCGCCATCCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCCTGGAGCTCG
AAAAAGCTGACCCGGACTTTATGGCTGAGCGCGGGGACGTTGTCAGCGACGAAGGACGGGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References