Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 660843..661375 | Replicon | chromosome |
| Accession | NZ_CP077863 | ||
| Organism | Staphylococcus aureus strain 371 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | Q93CD4 |
| Locus tag | KU524_RS03080 | Protein ID | WP_001103942.1 |
| Coordinates | 660843..661163 (-) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | - |
| Locus tag | KU524_RS03085 | Protein ID | WP_001058486.1 |
| Coordinates | 661166..661375 (-) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU524_RS03050 (655994) | 655994..656335 | - | 342 | WP_001190615.1 | hypothetical protein | - |
| KU524_RS03055 (656852) | 656852..657493 | - | 642 | WP_001019764.1 | hypothetical protein | - |
| KU524_RS03060 (657490) | 657490..657774 | - | 285 | WP_000998181.1 | hypothetical protein | - |
| KU524_RS03065 (657776) | 657776..658138 | - | 363 | WP_001039168.1 | hypothetical protein | - |
| KU524_RS03070 (658424) | 658424..659893 | - | 1470 | WP_000390454.1 | virulence-associated E family protein | - |
| KU524_RS03075 (659910) | 659910..660779 | - | 870 | WP_001002732.1 | primase alpha helix C-terminal domain-containing protein | - |
| KU524_RS03080 (660843) | 660843..661163 | - | 321 | WP_001103942.1 | DUF1474 family protein | Toxin |
| KU524_RS03085 (661166) | 661166..661375 | - | 210 | WP_001058486.1 | hypothetical protein | Antitoxin |
| KU524_RS03090 (661368) | 661368..661514 | - | 147 | WP_000784875.1 | hypothetical protein | - |
| KU524_RS03095 (661526) | 661526..661798 | - | 273 | WP_000091731.1 | helix-turn-helix domain-containing protein | - |
| KU524_RS03100 (661791) | 661791..662054 | - | 264 | WP_000243851.1 | helix-turn-helix transcriptional regulator | - |
| KU524_RS03105 (662247) | 662247..662579 | + | 333 | WP_001260004.1 | helix-turn-helix transcriptional regulator | - |
| KU524_RS03110 (662591) | 662591..663049 | + | 459 | WP_000281657.1 | ImmA/IrrE family metallo-endopeptidase | - |
| KU524_RS03115 (663066) | 663066..663497 | + | 432 | WP_001228759.1 | hypothetical protein | - |
| KU524_RS03120 (663567) | 663567..664295 | + | 729 | WP_001033316.1 | staphylococcal enterotoxin type Q | - |
| KU524_RS03125 (664319) | 664319..665047 | + | 729 | WP_000733774.1 | staphylococcal enterotoxin type K | - |
| KU524_RS03130 (665136) | 665136..666356 | + | 1221 | WP_225805722.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | seb / selq / selk | 651043..684390 | 33347 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12694.22 Da Isoelectric Point: 4.7419
>T208248 WP_001103942.1 NZ_CP077863:c661163-660843 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
Download Length: 321 bp
>T208248 NZ_CP103605:356749-357117 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTATTAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTATTAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8252.31 Da Isoelectric Point: 4.3718
>AT208248 WP_001058486.1 NZ_CP077863:c661375-661166 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT208248 NZ_CP103605:356531-356752 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|