Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 2207747..2208279 | Replicon | chromosome |
| Accession | NZ_CP077861 | ||
| Organism | Staphylococcus aureus strain 372 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | Q93CD4 |
| Locus tag | KU510_RS10870 | Protein ID | WP_001103942.1 |
| Coordinates | 2207959..2208279 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | - |
| Locus tag | KU510_RS10865 | Protein ID | WP_001058486.1 |
| Coordinates | 2207747..2207956 (+) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU510_RS10820 (2202766) | 2202766..2203986 | - | 1221 | WP_225805722.1 | site-specific integrase | - |
| KU510_RS10825 (2204075) | 2204075..2204803 | - | 729 | WP_000733774.1 | staphylococcal enterotoxin type K | - |
| KU510_RS10830 (2204827) | 2204827..2205555 | - | 729 | WP_001033316.1 | staphylococcal enterotoxin type Q | - |
| KU510_RS10835 (2205625) | 2205625..2206056 | - | 432 | WP_001228759.1 | hypothetical protein | - |
| KU510_RS10840 (2206073) | 2206073..2206531 | - | 459 | WP_000281657.1 | ImmA/IrrE family metallo-endopeptidase | - |
| KU510_RS10845 (2206543) | 2206543..2206875 | - | 333 | WP_001260004.1 | helix-turn-helix transcriptional regulator | - |
| KU510_RS10850 (2207068) | 2207068..2207331 | + | 264 | WP_000243851.1 | helix-turn-helix transcriptional regulator | - |
| KU510_RS10855 (2207324) | 2207324..2207596 | + | 273 | WP_000091731.1 | helix-turn-helix domain-containing protein | - |
| KU510_RS10860 (2207608) | 2207608..2207754 | + | 147 | WP_000784875.1 | hypothetical protein | - |
| KU510_RS10865 (2207747) | 2207747..2207956 | + | 210 | WP_001058486.1 | hypothetical protein | Antitoxin |
| KU510_RS10870 (2207959) | 2207959..2208279 | + | 321 | WP_001103942.1 | DUF1474 family protein | Toxin |
| KU510_RS10875 (2208343) | 2208343..2209212 | + | 870 | WP_001002732.1 | primase alpha helix C-terminal domain-containing protein | - |
| KU510_RS10880 (2209229) | 2209229..2210698 | + | 1470 | WP_000390454.1 | virulence-associated E family protein | - |
| KU510_RS10885 (2210984) | 2210984..2211346 | + | 363 | WP_001039168.1 | hypothetical protein | - |
| KU510_RS10890 (2211348) | 2211348..2211632 | + | 285 | WP_000998181.1 | hypothetical protein | - |
| KU510_RS10895 (2211629) | 2211629..2212270 | + | 642 | WP_001019764.1 | hypothetical protein | - |
| KU510_RS10900 (2212787) | 2212787..2213128 | + | 342 | WP_001190615.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp / selk / selq / seb | 2172073..2218079 | 46006 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12694.22 Da Isoelectric Point: 4.7419
>T208247 WP_001103942.1 NZ_CP077861:2207959-2208279 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
Download Length: 321 bp
>T208247 NZ_CP103600:12269-12547 [Escherichia coli]
ATGAAAATTAAAGAATATGATATTGCAGAACATTTGAACAGTGAAGAAGAAATGCAAATGTACCTCAATGAAATTATGGA
AGATGGTGAACCGTCATTAGTTCTTTCTGCATTGGGTGATATTGCCAGAGCCAGAAACATGAGCCAGCTTTCAAGAGAAG
TGGGAATGTCCAGAGAAGGGCTATATCATGCGTTATCAGGAAAAGGCAATCCAACATTCAGCGCCATGATGAAAATTACA
AAAGCGCTAGGCTTAAAACTTCACTTCACAGGGGCGTAA
ATGAAAATTAAAGAATATGATATTGCAGAACATTTGAACAGTGAAGAAGAAATGCAAATGTACCTCAATGAAATTATGGA
AGATGGTGAACCGTCATTAGTTCTTTCTGCATTGGGTGATATTGCCAGAGCCAGAAACATGAGCCAGCTTTCAAGAGAAG
TGGGAATGTCCAGAGAAGGGCTATATCATGCGTTATCAGGAAAAGGCAATCCAACATTCAGCGCCATGATGAAAATTACA
AAAGCGCTAGGCTTAAAACTTCACTTCACAGGGGCGTAA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8252.31 Da Isoelectric Point: 4.3718
>AT208247 WP_001058486.1 NZ_CP077861:2207747-2207956 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT208247 NZ_CP103600:11970-12272 [Escherichia coli]
ATGATAACGGTATTAAGTACAGAAATATTTGATAACTGGATTGATGCCCTTAAAGATGTCAGGGCTAAAACTAAGATTCA
GGCACGAATCCGCAGACTGAAAAATGGAAATTCCGGCGATATTGAACCTGTGGGCGAAGGGTTTTCAGAAATGCGGATTC
ATGAAGGGAAGGGCTACAGGGTTTATCTGAAAAAACACGGAAAGGTCATTGTTGTTTTGTTGTGTGGTGGAGATAAAAGT
ACACAACAAAAAGATATACTCAGAGCTAAAGCCATTTACAAAGAAATCGAGGGGGAGCTATGA
ATGATAACGGTATTAAGTACAGAAATATTTGATAACTGGATTGATGCCCTTAAAGATGTCAGGGCTAAAACTAAGATTCA
GGCACGAATCCGCAGACTGAAAAATGGAAATTCCGGCGATATTGAACCTGTGGGCGAAGGGTTTTCAGAAATGCGGATTC
ATGAAGGGAAGGGCTACAGGGTTTATCTGAAAAAACACGGAAAGGTCATTGTTGTTTTGTTGTGTGGTGGAGATAAAAGT
ACACAACAAAAAGATATACTCAGAGCTAAAGCCATTTACAAAGAAATCGAGGGGGAGCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|