Detailed information of TA system TA208246

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2190052..2190529
• Replicon: chromosome
• Accession: NZ_CP077861
• Organism: Staphylococcus aureus strain 372

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KU510_RS10725
• Protein ID: WP_000052076.1
• Coordinates: 2190052..2190240 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: KU510_RS10730
• Protein ID: WP_001059690.1
• Coordinates: 2190269..2190529 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU510_RS10695 (2186090)	2186090..2186560	+	471	WP_000824462.1	hypothetical protein	-
KU510_RS10700 (2186901)	2186901..2187587	+	687	WP_001823812.1	thermonuclease family protein	-
KU510_RS10705 (2187944)	2187944..2188144	+	201	WP_001059082.1	cold-shock protein	-
KU510_RS10710 (2188643)	2188643..2188861	-	219	WP_000005888.1	hypothetical protein	-
KU510_RS10715 (2188923)	2188923..2189207	-	285	WP_001004397.1	hypothetical protein	-
KU510_RS10720 (2189295)	2189295..2189864	-	570	WP_001106657.1	lipoprotein N-acylation protein LnsA	-
KU510_RS10725 (2190052)	2190052..2190240	-	189	WP_000052076.1	hypothetical protein	Toxin
KU510_RS10730 (2190269)	2190269..2190529	-	261	WP_001059690.1	hypothetical protein	Antitoxin
KU510_RS10735 (2190870)	2190870..2191073	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KU510_RS10740 (2191070)	2191070..2191306	-	237	WP_000368687.1	hypothetical protein	-
KU510_RS10745 (2191530)	2191530..2192111	+	582	WP_001140697.1	histidine phosphatase family protein	-
KU510_RS10750 (2192184)	2192184..2192801	-	618	WP_000255554.1	LysE/ArgO family amino acid transporter	-
KU510_RS10755 (2192957)	2192957..2193451	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
KU510_RS10760 (2193850)	2193850..2194272	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
KU510_RS10765 (2194420)	2194420..2195136	+	717	WP_000150029.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / selk / selq / seb	2172073..2218079	46006

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (44-87)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T208246 WP_000052076.1 NZ_CP077861:c2190240-2190052 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T208246 NZ_CP103600:11970-12272 [Escherichia coli]
ATGATAACGGTATTAAGTACAGAAATATTTGATAACTGGATTGATGCCCTTAAAGATGTCAGGGCTAAAACTAAGATTCA
GGCACGAATCCGCAGACTGAAAAATGGAAATTCCGGCGATATTGAACCTGTGGGCGAAGGGTTTTCAGAAATGCGGATTC
ATGAAGGGAAGGGCTACAGGGTTTATCTGAAAAAACACGGAAAGGTCATTGTTGTTTTGTTGTGTGGTGGAGATAAAAGT
ACACAACAAAAAGATATACTCAGAGCTAAAGCCATTTACAAAGAAATCGAGGGGGAGCTATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT208246 WP_001059690.1 NZ_CP077861:c2190529-2190269 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT208246 NZ_CP103600:12269-12547 [Escherichia coli]
ATGAAAATTAAAGAATATGATATTGCAGAACATTTGAACAGTGAAGAAGAAATGCAAATGTACCTCAATGAAATTATGGA
AGATGGTGAACCGTCATTAGTTCTTTCTGCATTGGGTGATATTGCCAGAGCCAGAAACATGAGCCAGCTTTCAAGAGAAG
TGGGAATGTCCAGAGAAGGGCTATATCATGCGTTATCAGGAAAAGGCAATCCAACATTCAGCGCCATGATGAAAATTACA
AAAGCGCTAGGCTTAAAACTTCACTTCACAGGGGCGTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56