208240

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 693639..694153 Replicon chromosome
Accession NZ_CP077861
Organism Staphylococcus aureus strain 372

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU510_RS03535 Protein ID WP_000581792.1
Coordinates 693639..693848 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag KU510_RS03540 Protein ID WP_000138934.1
Coordinates 693860..694153 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU510_RS03515 (689147) 689147..690505 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KU510_RS03520 (690520) 690520..691590 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
KU510_RS03525 (691908) 691908..693110 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU510_RS03530 (693374) 693374..693511 - 138 WP_000828354.1 Lmo0850 family protein -
KU510_RS03535 (693639) 693639..693848 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU510_RS03540 (693860) 693860..694153 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU510_RS03545 (694319) 694319..695803 + 1485 WP_000571549.1 cardiolipin synthase -
KU510_RS03550 (695831) 695831..696478 + 648 WP_001187610.1 HD domain-containing protein -
KU510_RS03555 (697293) 697293..698165 - 873 WP_000725802.1 membrane protein insertase YidC -
KU510_RS03560 (698251) 698251..698892 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208240 WP_000581792.1 NZ_CP077861:c693848-693639 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208240 NZ_CP103596:c3988124-3987837 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT208240 WP_000138934.1 NZ_CP077861:c694153-693860 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208240 NZ_CP103596:c3987850-3987548 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References