Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2526940..2527417 Replicon chromosome
Accession NZ_CP077860
Organism Staphylococcus aureus strain AC4

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU521_RS12420 Protein ID WP_000052076.1
Coordinates 2526940..2527128 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU521_RS12425 Protein ID WP_001059690.1
Coordinates 2527157..2527417 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU521_RS12390 (2522934) 2522934..2523455 + 522 WP_000824482.1 hypothetical protein -
KU521_RS12395 (2523796) 2523796..2524482 + 687 WP_000141557.1 thermonuclease family protein -
KU521_RS12400 (2524839) 2524839..2525039 + 201 WP_001059082.1 cold-shock protein -
KU521_RS12405 (2525531) 2525531..2525749 - 219 WP_000005886.1 hypothetical protein -
KU521_RS12410 (2525811) 2525811..2526095 - 285 WP_001004399.1 hypothetical protein -
KU521_RS12415 (2526183) 2526183..2526752 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KU521_RS12420 (2526940) 2526940..2527128 - 189 WP_000052076.1 hypothetical protein Toxin
KU521_RS12425 (2527157) 2527157..2527417 - 261 WP_001059690.1 hypothetical protein Antitoxin
KU521_RS12430 (2527758) 2527758..2527961 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU521_RS12435 (2527958) 2527958..2528194 - 237 WP_000349581.1 hypothetical protein -
KU521_RS12440 (2528419) 2528419..2529000 + 582 WP_001140693.1 histidine phosphatase family protein -
KU521_RS12445 (2529073) 2529073..2529690 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
KU521_RS12450 (2529845) 2529845..2530339 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU521_RS12455 (2530738) 2530738..2531160 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
KU521_RS12460 (2531308) 2531308..2532024 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208234 WP_000052076.1 NZ_CP077860:c2527128-2526940 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208234 NZ_CP103596:c2421474-2421298 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208234 WP_001059690.1 NZ_CP077860:c2527417-2527157 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208234 NZ_CP103596:c2421252-2420836 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References