Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2171075..2171598 Replicon chromosome
Accession NZ_CP077859
Organism Staphylococcus aureus strain AC5

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag KU537_RS10455 Protein ID WP_000074049.1
Coordinates 2171332..2171598 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag KU537_RS10450 Protein ID WP_000587616.1
Coordinates 2171075..2171332 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU537_RS10435 (2167572) 2167572..2168321 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
KU537_RS10440 (2168516) 2168516..2170093 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
KU537_RS10445 (2170261) 2170261..2170716 - 456 WP_000732076.1 DUF1307 domain-containing protein -
KU537_RS10450 (2171075) 2171075..2171332 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU537_RS10455 (2171332) 2171332..2171598 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
KU537_RS10460 (2171953) 2171953..2173029 + 1077 WP_001076673.1 M42 family metallopeptidase -
KU537_RS10465 (2173277) 2173277..2173939 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
KU537_RS10470 (2173932) 2173932..2174708 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
KU537_RS10475 (2175104) 2175104..2176291 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T208205 WP_000074049.1 NZ_CP077859:2171332-2171598 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T208205 NZ_CP103592:1933363-1933614 [Escherichia coli O25b:H4-ST131]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT208205 WP_000587616.1 NZ_CP077859:2171075-2171332 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT208205 NZ_CP103592:1933611-1933865 [Escherichia coli O25b:H4-ST131]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References