Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1077649..1078126 Replicon chromosome
Accession NZ_CP077859
Organism Staphylococcus aureus strain AC5

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU537_RS05300 Protein ID WP_000052076.1
Coordinates 1077938..1078126 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU537_RS05295 Protein ID WP_001059690.1
Coordinates 1077649..1077909 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU537_RS05260 (1073042) 1073042..1073758 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
KU537_RS05265 (1073906) 1073906..1074328 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
KU537_RS05270 (1074727) 1074727..1075221 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU537_RS05275 (1075376) 1075376..1075993 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
KU537_RS05280 (1076066) 1076066..1076647 - 582 WP_001140693.1 histidine phosphatase family protein -
KU537_RS05285 (1076872) 1076872..1077108 + 237 WP_000349581.1 hypothetical protein -
KU537_RS05290 (1077105) 1077105..1077308 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU537_RS05295 (1077649) 1077649..1077909 + 261 WP_001059690.1 hypothetical protein Antitoxin
KU537_RS05300 (1077938) 1077938..1078126 + 189 WP_000052076.1 hypothetical protein Toxin
KU537_RS05305 (1078314) 1078314..1078883 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KU537_RS05310 (1078971) 1078971..1079255 + 285 WP_001004399.1 hypothetical protein -
KU537_RS05315 (1079317) 1079317..1079535 + 219 WP_000005886.1 hypothetical protein -
KU537_RS05320 (1080027) 1080027..1080227 - 201 WP_001059082.1 cold-shock protein -
KU537_RS05325 (1080584) 1080584..1081270 - 687 WP_000141557.1 thermonuclease family protein -
KU537_RS05330 (1081611) 1081611..1082132 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1015595..1083489 67894


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208204 WP_000052076.1 NZ_CP077859:1077938-1078126 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208204 NZ_CP103592:964626-965033 [Escherichia coli O25b:H4-ST131]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208204 WP_001059690.1 NZ_CP077859:1077649-1077909 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208204 NZ_CP103592:964379-964645 [Escherichia coli O25b:H4-ST131]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References