Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2563386..2563900 Replicon chromosome
Accession NZ_CP077858
Organism Staphylococcus aureus strain AC6

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU543_RS12605 Protein ID WP_000581792.1
Coordinates 2563691..2563900 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU543_RS12600 Protein ID WP_000138932.1
Coordinates 2563386..2563679 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU543_RS12580 (2558649) 2558649..2559290 + 642 WP_000483153.1 thiamine phosphate synthase -
KU543_RS12585 (2559376) 2559376..2560248 + 873 WP_000725802.1 membrane protein insertase YidC -
KU543_RS12590 (2561061) 2561061..2561708 - 648 WP_001187630.1 HD domain-containing protein -
KU543_RS12595 (2561736) 2561736..2563220 - 1485 WP_000571549.1 cardiolipin synthase -
KU543_RS12600 (2563386) 2563386..2563679 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU543_RS12605 (2563691) 2563691..2563900 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU543_RS12610 (2564028) 2564028..2564165 + 138 WP_000828354.1 Lmo0850 family protein -
KU543_RS12615 (2564429) 2564429..2565631 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU543_RS12620 (2565949) 2565949..2567019 + 1071 WP_225798614.1 D-alanine--D-alanine ligase -
KU543_RS12625 (2567034) 2567034..2568392 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208196 WP_000581792.1 NZ_CP077858:2563691-2563900 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208196 NZ_CP103591:c76447-76031 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208196 WP_000138932.1 NZ_CP077858:2563386-2563679 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208196 NZ_CP103591:c76674-76444 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References