Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2188420..2188943 Replicon chromosome
Accession NZ_CP077858
Organism Staphylococcus aureus strain AC6

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag KU543_RS10660 Protein ID WP_000074049.1
Coordinates 2188677..2188943 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag KU543_RS10655 Protein ID WP_000587616.1
Coordinates 2188420..2188677 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU543_RS10640 (2184917) 2184917..2185666 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
KU543_RS10645 (2185861) 2185861..2187438 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
KU543_RS10650 (2187606) 2187606..2188061 - 456 WP_000732076.1 DUF1307 domain-containing protein -
KU543_RS10655 (2188420) 2188420..2188677 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU543_RS10660 (2188677) 2188677..2188943 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
KU543_RS10665 (2189298) 2189298..2190374 + 1077 WP_001076673.1 M42 family metallopeptidase -
KU543_RS10670 (2190622) 2190622..2191284 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
KU543_RS10675 (2191277) 2191277..2192053 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
KU543_RS10680 (2192449) 2192449..2193636 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T208188 WP_000074049.1 NZ_CP077858:2188677-2188943 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T208188 NZ_CP103589:c4222942-4222628 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT208188 WP_000587616.1 NZ_CP077858:2188420-2188677 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT208188 NZ_CP103589:c4223178-4222945 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References