Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1094994..1095471 Replicon chromosome
Accession NZ_CP077858
Organism Staphylococcus aureus strain AC6

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU543_RS05505 Protein ID WP_000052076.1
Coordinates 1095283..1095471 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU543_RS05500 Protein ID WP_001059690.1
Coordinates 1094994..1095254 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU543_RS05465 (1090387) 1090387..1091103 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
KU543_RS05470 (1091251) 1091251..1091673 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
KU543_RS05475 (1092072) 1092072..1092566 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU543_RS05480 (1092721) 1092721..1093338 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
KU543_RS05485 (1093411) 1093411..1093992 - 582 WP_001140693.1 histidine phosphatase family protein -
KU543_RS05490 (1094217) 1094217..1094453 + 237 WP_000349581.1 hypothetical protein -
KU543_RS05495 (1094450) 1094450..1094653 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU543_RS05500 (1094994) 1094994..1095254 + 261 WP_001059690.1 hypothetical protein Antitoxin
KU543_RS05505 (1095283) 1095283..1095471 + 189 WP_000052076.1 hypothetical protein Toxin
KU543_RS05510 (1095659) 1095659..1096228 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KU543_RS05515 (1096316) 1096316..1096600 + 285 WP_001004399.1 hypothetical protein -
KU543_RS05520 (1096662) 1096662..1096880 + 219 WP_000005886.1 hypothetical protein -
KU543_RS05525 (1097372) 1097372..1097572 - 201 WP_001059082.1 cold-shock protein -
KU543_RS05530 (1097929) 1097929..1098615 - 687 WP_000141557.1 thermonuclease family protein -
KU543_RS05535 (1098956) 1098956..1099477 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208187 WP_000052076.1 NZ_CP077858:1095283-1095471 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208187 NZ_CP103589:c3947994-3947596 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208187 WP_001059690.1 NZ_CP077858:1094994-1095254 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208187 NZ_CP103589:c3948290-3947997 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References