Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 16093..16869 Replicon chromosome
Accession NZ_CP077858
Organism Staphylococcus aureus strain AC6

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag KU543_RS00205 Protein ID WP_000031108.1
Coordinates 16717..16869 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag KU543_RS00200 Protein ID WP_001251224.1
Coordinates 16093..16692 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU543_RS00180 (12009) 12009..13466 + 1458 WP_000649908.1 ABC transporter permease subunit -
KU543_RS00185 (13459) 13459..14181 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
KU543_RS00190 (14332) 14332..15459 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
KU543_RS00195 (15464) 15464..15934 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KU543_RS00200 (16093) 16093..16692 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
KU543_RS00205 (16717) 16717..16869 + 153 WP_000031108.1 SAS053 family protein Toxin
KU543_RS00210 (17417) 17417..17812 + 396 WP_000901023.1 hypothetical protein -
KU543_RS00215 (18008) 18008..19393 + 1386 WP_000116228.1 class II fumarate hydratase -
KU543_RS00220 (19846) 19846..20667 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T208184 WP_000031108.1 NZ_CP077858:16717-16869 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T208184 NZ_CP103589:2954262-2954369 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT208184 WP_001251224.1 NZ_CP077858:16093-16692 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT208184 NZ_CP103589:c2954209-2954148 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References