Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2562906..2563420 Replicon chromosome
Accession NZ_CP077857
Organism Staphylococcus aureus strain L4

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU533_RS12600 Protein ID WP_000581792.1
Coordinates 2563211..2563420 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU533_RS12595 Protein ID WP_000138932.1
Coordinates 2562906..2563199 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU533_RS12575 (2558169) 2558169..2558810 + 642 WP_000483153.1 thiamine phosphate synthase -
KU533_RS12580 (2558896) 2558896..2559768 + 873 WP_000725802.1 membrane protein insertase YidC -
KU533_RS12585 (2560581) 2560581..2561228 - 648 WP_001187630.1 HD domain-containing protein -
KU533_RS12590 (2561256) 2561256..2562740 - 1485 WP_000571549.1 cardiolipin synthase -
KU533_RS12595 (2562906) 2562906..2563199 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU533_RS12600 (2563211) 2563211..2563420 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU533_RS12605 (2563548) 2563548..2563685 + 138 WP_000828354.1 Lmo0850 family protein -
KU533_RS12610 (2563949) 2563949..2565151 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU533_RS12615 (2565469) 2565469..2566539 + 1071 WP_225798614.1 D-alanine--D-alanine ligase -
KU533_RS12620 (2566554) 2566554..2567912 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208178 WP_000581792.1 NZ_CP077857:2563211-2563420 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208178 NZ_CP103589:955856-956263 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208178 WP_000138932.1 NZ_CP077857:2562906-2563199 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208178 NZ_CP103589:955609-955875 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References