Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1094528..1095005 Replicon chromosome
Accession NZ_CP077857
Organism Staphylococcus aureus strain L4

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU533_RS05500 Protein ID WP_000052076.1
Coordinates 1094817..1095005 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU533_RS05495 Protein ID WP_001059690.1
Coordinates 1094528..1094788 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU533_RS05460 (1089921) 1089921..1090637 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
KU533_RS05465 (1090785) 1090785..1091207 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
KU533_RS05470 (1091606) 1091606..1092100 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU533_RS05475 (1092255) 1092255..1092872 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
KU533_RS05480 (1092945) 1092945..1093526 - 582 WP_001140693.1 histidine phosphatase family protein -
KU533_RS05485 (1093751) 1093751..1093987 + 237 WP_000349581.1 hypothetical protein -
KU533_RS05490 (1093984) 1093984..1094187 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU533_RS05495 (1094528) 1094528..1094788 + 261 WP_001059690.1 hypothetical protein Antitoxin
KU533_RS05500 (1094817) 1094817..1095005 + 189 WP_000052076.1 hypothetical protein Toxin
KU533_RS05505 (1095193) 1095193..1095762 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KU533_RS05510 (1095850) 1095850..1096134 + 285 WP_001004399.1 hypothetical protein -
KU533_RS05515 (1096196) 1096196..1096414 + 219 WP_000005886.1 hypothetical protein -
KU533_RS05520 (1096906) 1096906..1097106 - 201 WP_001059082.1 cold-shock protein -
KU533_RS05525 (1097463) 1097463..1098149 - 687 WP_000141557.1 thermonuclease family protein -
KU533_RS05530 (1098490) 1098490..1099011 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208169 WP_000052076.1 NZ_CP077857:1094817-1095005 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208169 NZ_CP103586:c4703126-4702593 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208169 WP_001059690.1 NZ_CP077857:1094528-1094788 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208169 NZ_CP103586:c4703403-4703137 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References