Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsaAT/- |
Location | 1082481..1082958 | Replicon | chromosome |
Accession | NZ_CP077856 | ||
Organism | Staphylococcus aureus strain L5 |
Toxin (Protein)
Gene name | TsaT | Uniprot ID | T1Y7S2 |
Locus tag | KU529_RS05330 | Protein ID | WP_000052076.1 |
Coordinates | 1082770..1082958 (+) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | TsaA | Uniprot ID | T1Y6P8 |
Locus tag | KU529_RS05325 | Protein ID | WP_001059690.1 |
Coordinates | 1082481..1082741 (+) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KU529_RS05290 (1077874) | 1077874..1078590 | - | 717 | WP_000150011.1 | type I 3-dehydroquinate dehydratase | - |
KU529_RS05295 (1078738) | 1078738..1079160 | + | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
KU529_RS05300 (1079559) | 1079559..1080053 | + | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
KU529_RS05305 (1080208) | 1080208..1080825 | + | 618 | WP_000255551.1 | LysE/ArgO family amino acid transporter | - |
KU529_RS05310 (1080898) | 1080898..1081479 | - | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
KU529_RS05315 (1081704) | 1081704..1081940 | + | 237 | WP_000349581.1 | hypothetical protein | - |
KU529_RS05320 (1081937) | 1081937..1082140 | - | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
KU529_RS05325 (1082481) | 1082481..1082741 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
KU529_RS05330 (1082770) | 1082770..1082958 | + | 189 | WP_000052076.1 | hypothetical protein | Toxin |
KU529_RS05335 (1083146) | 1083146..1083715 | + | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
KU529_RS05340 (1083803) | 1083803..1084087 | + | 285 | WP_001004399.1 | hypothetical protein | - |
KU529_RS05345 (1084149) | 1084149..1084367 | + | 219 | WP_000005886.1 | hypothetical protein | - |
KU529_RS05350 (1084859) | 1084859..1085059 | - | 201 | WP_001059082.1 | cold-shock protein | - |
KU529_RS05355 (1085416) | 1085416..1086102 | - | 687 | WP_000141557.1 | thermonuclease family protein | - |
KU529_RS05360 (1086443) | 1086443..1086964 | - | 522 | WP_000824482.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T208151 WP_000052076.1 NZ_CP077856:1082770-1082958 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T208151 NZ_CP103582:1892519-1892621 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT208151 WP_001059690.1 NZ_CP077856:1082481-1082741 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT208151 NZ_CP103582:c1892628-1892483 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VP18 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VN56 |