Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1082481..1082958 Replicon chromosome
Accession NZ_CP077856
Organism Staphylococcus aureus strain L5

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU529_RS05330 Protein ID WP_000052076.1
Coordinates 1082770..1082958 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU529_RS05325 Protein ID WP_001059690.1
Coordinates 1082481..1082741 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU529_RS05290 (1077874) 1077874..1078590 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
KU529_RS05295 (1078738) 1078738..1079160 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
KU529_RS05300 (1079559) 1079559..1080053 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU529_RS05305 (1080208) 1080208..1080825 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
KU529_RS05310 (1080898) 1080898..1081479 - 582 WP_001140693.1 histidine phosphatase family protein -
KU529_RS05315 (1081704) 1081704..1081940 + 237 WP_000349581.1 hypothetical protein -
KU529_RS05320 (1081937) 1081937..1082140 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU529_RS05325 (1082481) 1082481..1082741 + 261 WP_001059690.1 hypothetical protein Antitoxin
KU529_RS05330 (1082770) 1082770..1082958 + 189 WP_000052076.1 hypothetical protein Toxin
KU529_RS05335 (1083146) 1083146..1083715 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KU529_RS05340 (1083803) 1083803..1084087 + 285 WP_001004399.1 hypothetical protein -
KU529_RS05345 (1084149) 1084149..1084367 + 219 WP_000005886.1 hypothetical protein -
KU529_RS05350 (1084859) 1084859..1085059 - 201 WP_001059082.1 cold-shock protein -
KU529_RS05355 (1085416) 1085416..1086102 - 687 WP_000141557.1 thermonuclease family protein -
KU529_RS05360 (1086443) 1086443..1086964 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208151 WP_000052076.1 NZ_CP077856:1082770-1082958 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208151 NZ_CP103582:1892519-1892621 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208151 WP_001059690.1 NZ_CP077856:1082481-1082741 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208151 NZ_CP103582:c1892628-1892483 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References