Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1607012..1607489 Replicon chromosome
Accession NZ_CP077855
Organism Staphylococcus aureus strain L6

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU520_RS08265 Protein ID WP_000052076.1
Coordinates 1607301..1607489 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU520_RS08260 Protein ID WP_001059690.1
Coordinates 1607012..1607272 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU520_RS08225 (1602405) 1602405..1603121 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
KU520_RS08230 (1603269) 1603269..1603691 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
KU520_RS08235 (1604090) 1604090..1604584 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU520_RS08240 (1604739) 1604739..1605356 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
KU520_RS08245 (1605429) 1605429..1606010 - 582 WP_001140693.1 histidine phosphatase family protein -
KU520_RS08250 (1606235) 1606235..1606471 + 237 WP_000349581.1 hypothetical protein -
KU520_RS08255 (1606468) 1606468..1606671 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU520_RS08260 (1607012) 1607012..1607272 + 261 WP_001059690.1 hypothetical protein Antitoxin
KU520_RS08265 (1607301) 1607301..1607489 + 189 WP_000052076.1 hypothetical protein Toxin
KU520_RS08270 (1607677) 1607677..1608246 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KU520_RS08275 (1608334) 1608334..1608618 + 285 WP_001004399.1 hypothetical protein -
KU520_RS08280 (1608680) 1608680..1608898 + 219 WP_000005886.1 hypothetical protein -
KU520_RS08285 (1609390) 1609390..1609590 - 201 WP_001059082.1 cold-shock protein -
KU520_RS08290 (1609947) 1609947..1610633 - 687 WP_000141557.1 thermonuclease family protein -
KU520_RS08295 (1610974) 1610974..1611495 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208143 WP_000052076.1 NZ_CP077855:1607301-1607489 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208143 NZ_CP103579:c4706831-4706547 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208143 WP_001059690.1 NZ_CP077855:1607012-1607272 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208143 NZ_CP103579:c4707063-4706821 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References