Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 308412..308926 Replicon chromosome
Accession NZ_CP077855
Organism Staphylococcus aureus strain L6

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KU520_RS01620 Protein ID WP_000581792.1
Coordinates 308717..308926 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KU520_RS01615 Protein ID WP_000138932.1
Coordinates 308412..308705 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU520_RS01595 (303675) 303675..304316 + 642 WP_000483153.1 thiamine phosphate synthase -
KU520_RS01600 (304402) 304402..305274 + 873 WP_000725802.1 membrane protein insertase YidC -
KU520_RS01605 (306087) 306087..306734 - 648 WP_001187630.1 HD domain-containing protein -
KU520_RS01610 (306762) 306762..308246 - 1485 WP_000571549.1 cardiolipin synthase -
KU520_RS01615 (308412) 308412..308705 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KU520_RS01620 (308717) 308717..308926 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KU520_RS01625 (309054) 309054..309191 + 138 WP_000828354.1 Lmo0850 family protein -
KU520_RS01630 (309455) 309455..310657 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KU520_RS01635 (310975) 310975..312045 + 1071 WP_225798614.1 D-alanine--D-alanine ligase -
KU520_RS01640 (312060) 312060..313418 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T208134 WP_000581792.1 NZ_CP077855:308717-308926 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T208134 NZ_CP103577:c4221406-4221221 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT208134 WP_000138932.1 NZ_CP077855:308412-308705 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT208134 NZ_CP103577:c4221206-4220802 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCTGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGATGCTTTTCAGGATGCACGTGATGCGCTCACGGCGCACCTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCACTTCCGGGTAATGTCGAAGTGCACCTTGAAAATCAACCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAATTCGACGGCAGAGCCGAACGCATAAACATCACGATGCCTCGACGTTTGCTGGTGAA
GATTGACTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTCCTGGCCGAGGCAGCACGTCGCGTACTGC
CGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References