Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1659708..1660185 Replicon chromosome
Accession NZ_CP077854
Organism Staphylococcus aureus strain N4

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KU508_RS08190 Protein ID WP_000052076.1
Coordinates 1659708..1659896 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KU508_RS08195 Protein ID WP_001059690.1
Coordinates 1659925..1660185 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU508_RS08160 (1655702) 1655702..1656223 + 522 WP_000824482.1 hypothetical protein -
KU508_RS08165 (1656564) 1656564..1657250 + 687 WP_000141557.1 thermonuclease family protein -
KU508_RS08170 (1657607) 1657607..1657807 + 201 WP_001059082.1 cold-shock protein -
KU508_RS08175 (1658299) 1658299..1658517 - 219 WP_000005886.1 hypothetical protein -
KU508_RS08180 (1658579) 1658579..1658863 - 285 WP_001004399.1 hypothetical protein -
KU508_RS08185 (1658951) 1658951..1659520 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KU508_RS08190 (1659708) 1659708..1659896 - 189 WP_000052076.1 hypothetical protein Toxin
KU508_RS08195 (1659925) 1659925..1660185 - 261 WP_001059690.1 hypothetical protein Antitoxin
KU508_RS08200 (1660526) 1660526..1660729 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KU508_RS08205 (1660726) 1660726..1660962 - 237 WP_000349581.1 hypothetical protein -
KU508_RS08210 (1661187) 1661187..1661768 + 582 WP_001140693.1 histidine phosphatase family protein -
KU508_RS08215 (1661841) 1661841..1662458 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
KU508_RS08220 (1662613) 1662613..1663107 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KU508_RS08225 (1663506) 1663506..1663928 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
KU508_RS08230 (1664076) 1664076..1664792 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T208126 WP_000052076.1 NZ_CP077854:c1659896-1659708 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T208126 NZ_CP103577:c299882-299595 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT208126 WP_001059690.1 NZ_CP077854:c1660185-1659925 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT208126 NZ_CP103577:c300191-299889 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
CTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCTGTGGGAGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References