Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 240669..241281 Replicon chromosome
Accession NC_004368
Organism Streptococcus agalactiae NEM316

Toxin (Protein)


Gene name parE Uniprot ID Q8E7D3
Locus tag GBS_RS01385 Protein ID WP_000384859.1
Coordinates 240669..241004 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E7D2
Locus tag GBS_RS01390 Protein ID WP_000259017.1
Coordinates 240994..241281 (-) Length 96 a.a.

Genomic Context

GBS_RS01355GBS_RS01365GBS_RS01370GBS_RS01375GBS_RS01380GBS_RS01395GBS_RS01400GBS_RS01405GBS_RS01410GBS_RS01415GBS_RS01420GBS_RS01425GBS_RS01385GBS_RS01390
Location: 235886..236527 (642 bp)
Type: Others
Protein ID: WP_000591144.1
Location: 236827..237615 (789 bp)
Type: Others
Protein ID: WP_011074702.1
Location: 237719..238153 (435 bp)
Type: Others
Protein ID: WP_001220479.1
Location: 238470..239726 (1257 bp)
Type: Others
Protein ID: WP_000122836.1
Location: 239894..240364 (471 bp)
Type: Others
Protein ID: WP_000130119.1
Location: 241789..242079 (291 bp)
Type: Others
Protein ID: WP_000078282.1
Location: 242181..242588 (408 bp)
Type: Others
Protein ID: WP_000749962.1
Location: 242674..243081 (408 bp)
Type: Others
Protein ID: WP_000749955.1
Location: 243081..243668 (588 bp)
Type: Others
Protein ID: WP_011074703.1
Location: 244050..244292 (243 bp)
Type: Others
Protein ID: WP_001134681.1
Location: 244277..244663 (387 bp)
Type: Others
Protein ID: WP_000259072.1
Location: 244697..244978 (282 bp)
Type: Others
Protein ID: WP_000052404.1
Location: 240669..241004 (336 bp)
Type: Toxin
Protein ID: WP_000384859.1
Location: 240994..241281 (288 bp)
Type: Antitoxin
Protein ID: WP_000259017.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GBS_RS01355235886..236527+642WP_000591144.1hypothetical protein-
GBS_RS01365236827..237615+789WP_011074702.1hypothetical protein-
GBS_RS01370237719..238153+435WP_001220479.1hypothetical protein-
GBS_RS01375238470..239726+1257WP_000122836.1plasmid recombination protein-
GBS_RS01380239894..240364+471WP_000130119.1hypothetical protein-
GBS_RS01385240669..241004-336WP_000384859.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GBS_RS01390240994..241281-288WP_000259017.1hypothetical proteinAntitoxin
GBS_RS01395241789..242079+291WP_000078282.1WXG100 family type VII secretion target-
GBS_RS01400242181..242588+408WP_000749962.1hypothetical protein-
GBS_RS01405242674..243081+408WP_000749955.1hypothetical protein-
GBS_RS01410243081..243668+588WP_011074703.1hypothetical protein-
GBS_RS01415244050..244292+243WP_001134681.1hypothetical protein-
GBS_RS01420244277..244663+387WP_000259072.1hypothetical protein-
GBS_RS01425244697..244978+282WP_000052404.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13296.98 Da        Isoelectric Point: 4.6565

>T20812 WP_000384859.1 NC_004368:c241004-240669 [Streptococcus agalactiae NEM316]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T20812 NC_004368:c241004-240669 [Streptococcus agalactiae NEM316]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.7271

>AT20812 WP_000259017.1 NC_004368:c241281-240994 [Streptococcus agalactiae NEM316]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT20812 NC_004368:c241281-240994 [Streptococcus agalactiae NEM316]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A076Z4V6

References