Detailed information of TA system TA020812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 240669..241281
• Replicon: chromosome
• Accession: NC_004368
• Organism: Streptococcus agalactiae NEM316

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: GBS_RS01385
• Protein ID: WP_000384859.1
• Coordinates: 240669..241004 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: GBS_RS01390
• Protein ID: WP_000259017.1
• Coordinates: 240994..241281 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GBS_RS01355	235886..236527	+	642	WP_000591144.1	hypothetical protein	-
GBS_RS01365	236827..237615	+	789	WP_011074702.1	hypothetical protein	-
GBS_RS01370	237719..238153	+	435	WP_001220479.1	hypothetical protein	-
GBS_RS01375	238470..239726	+	1257	WP_000122836.1	plasmid recombination protein	-
GBS_RS01380	239894..240364	+	471	WP_000130119.1	hypothetical protein	-
GBS_RS01385	240669..241004	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GBS_RS01390	240994..241281	-	288	WP_000259017.1	hypothetical protein	Antitoxin
GBS_RS01395	241789..242079	+	291	WP_000078282.1	WXG100 family type VII secretion target	-
GBS_RS01400	242181..242588	+	408	WP_000749962.1	hypothetical protein	-
GBS_RS01405	242674..243081	+	408	WP_000749955.1	hypothetical protein	-
GBS_RS01410	243081..243668	+	588	WP_011074703.1	hypothetical protein	-
GBS_RS01415	244050..244292	+	243	WP_001134681.1	hypothetical protein	-
GBS_RS01420	244277..244663	+	387	WP_000259072.1	hypothetical protein	-
GBS_RS01425	244697..244978	+	282	WP_000052404.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T20812 WP_000384859.1 NC_004368:c241004-240669 [Streptococcus agalactiae NEM316]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T20812 NC_004368:c241004-240669 [Streptococcus agalactiae NEM316]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT20812 WP_000259017.1 NC_004368:c241281-240994 [Streptococcus agalactiae NEM316]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT20812 NC_004368:c241281-240994 [Streptococcus agalactiae NEM316]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6